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Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup

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العنوان: Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup
المؤلفون: Leontien C.M. Kremer, Daniela Alessi, Thomas Wiebe, Roderick Skinner, Vera Morsellino, Gisela Michel, Melanie Kaiser, Finn Wesenberg, Rodrigue S. Allodji, Claudia E. Kuehni, David L. Winter, Päivi M. Lähteenmäki, Jeanette Falck Winther, Momcilo Jankovic, Neige Journy, Eva-Maria Hau, Zsuzsanna Jakab, Andrea Bautz, Michael M. Hawkins, Jop C Teepen, Imene Mansouri, Joyeeta Guha, Florent de Vathaire, Giao Vu-Bezin, Edit Bardi, Carlotta Sacerdote, Lorna Zadravec Zaletel, Damien Llanas, Peter Kaatsch, Lars Hjorth, Cécile M. Ronckers, Carole Rubino, Nadia Haddy, Monica Muraca, Julianne Byrne, Thorgerdur Gudmundsdottir, Ibrahima Diallo, Stanislaw Garwicz, Monica Terenziani, Hilde Øfstaas, Helena M. Linge, Chloe J Bright, Brice Fresneau, Miranda M Fidler-Benaoudia, Elizabeth Lieke A.M. Feijen, Cristina Veres, Riccardo Haupt, Raoul C. Reulen, Desiree Grabow
المساهمون: Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Graduate School, CCA - Cancer Treatment and Quality of Life, ARD - Amsterdam Reproduction and Development, Paediatric Oncology
المصدر: European Journal of Cancer
European Journal of Cancer, Elsevier, 2019, 117, pp.71-83. ⟨10.1016/j.ejca.2019.05.013⟩
European journal of cancer (Oxford, England, 117, 71-83. Elsevier Limited
Allodji, R S, Hawkins, M M, Bright, C J, Fidler-Benaoudia, M M, Winter, D L, Alessi, D, Fresneau, B, Journy, N, Morsellino, V, Bárdi, E, Bautz, A, Byrne, J, Feijen, E AM, Teepen, J C, Vu-Bezin, G, Rubino, C, Garwicz, S, Grabow, D, Gudmundsdottir, T, Guha, J, Hau, E M, Jankovic, M, Kaatsch, P, Kaiser, M, Linge, H, Muraca, M, Llanas, D, Veres, C, Øfstaas, H, Diallo, I, Mansouri, I, Ronckers, C M, Skinner, R, Terenziani, M, Wesenberg, F, Wiebe, T, Sacerdote, C, Jakab, Z, Haupt, R, Lähteenmäki, P, Zaletel, L Z, Kuehni, C E, Winther, J F, Michel, G, Kremer, L C M, Hjorth, L, Haddy, N, de Vathaire, F & Reulen, R C 2019, ' Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe : A cohort study within PanCareSurFup ', European Journal of Cancer, vol. 117, pp. 71-83 . https://doi.org/10.1016/j.ejca.2019.05.013
بيانات النشر: HAL CCSD, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Pediatrics, Myeloid, [SDV]Life Sciences [q-bio], Childhood cancer survivors, Cohort Studies, 0302 clinical medicine, Cancer Survivors, Risk Factors, Registries, Child, Myeloid leukaemias, education.field_of_study, Leukemia, Incidence, Incidence (epidemiology), Neoplasms, Second Primary, Prognosis, 3. Good health, Europe, medicine.anatomical_structure, Second cancers, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, Cohort, Female, Cohort study, Adult, medicine.medical_specialty, Adolescent, Population, Subsequent primary leukaemia, Risk Assessment, Young Adult, 03 medical and health sciences, medicine, Humans, education, business.industry, Infant, Newborn, Infant, Cancer, medicine.disease, Confidence interval, 030104 developmental biology, Relative risk, business, Lymphoid leukaemias, Follow-Up Studies
الوصف: Background Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors. Methods This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries. Standardised incidence ratios (SIRs) and absolute excess risks (AERs) were calculated. Results One hundred fifteen survivors developed an SPL including 86 myeloid leukaemias (subsequent primary myeloid leukaemias [SPMLs]), 17 lymphoid leukaemias and 12 other types of leukaemias; of these SPLs, 31 (27%) occurred beyond 20 years from the first childhood cancer diagnosis. Compared with the general population, childhood cancer survivors had a fourfold increased risk (SIR = 3.7, 95% confidence interval [CI]: 3.1 to 4.5) of developing leukaemia, and eight leukaemias per 100,000 person-years (AER = 7.5, 95% CI: 6.0 to 9.2) occurred in excess of that expected. The risks remained significantly elevated beyond 20 years from the first primary malignancy (SIR = 2.4, 95% CI: 1.6 to 3.4). Overall, the risk ratio for SPML (SIR = 5.8, 95% CI: 4.6 to 7.1) was higher than that for other SPLs. Conclusions We demonstrate that beyond 20 years after childhood cancer diagnosis, survivors experience an increased risk for SPLs compared with that expected from the general population. Our findings highlight the need for awareness by survivors and their healthcare providers for potential risk related to SPL.
اللغة: English
تدمد: 0959-8049
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4072a5715aa5f296348ff573425816
https://hal.archives-ouvertes.fr/hal-03480680/file/S0959804919303168.pdf
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....0e4072a5715aa5f296348ff573425816
قاعدة البيانات: OpenAIRE
الوصف
تدمد:09598049