OpenFluDB, a database for human and animal influenza virus
| العنوان: | OpenFluDB, a database for human and animal influenza virus |
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| المؤلفون: | Dmitry Kuznetsov, Lydie Bougueleret, Anne Gleizes, Robin Liechti, Amos Marc Bairoch, Ioannis Xenarios, Philippe Le Mercier |
| المصدر: | Database: The Journal of Biological Databases and Curation Database, vol. 2010, pp. baq004 Scopus-Elsevier Database, Vol. 2010 (2010) P. baq004 |
| بيانات النشر: | Oxford University Press (OUP), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Swine, Orthomyxoviridae, Sequence alignment, Genome, Viral, computer.software_genre, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Virus, Birds, Evolution, Molecular, User-Computer Interface, Influenza A Virus, H1N1 Subtype, Orthomyxoviridae Infections, Databases, Genetic, Influenza, Human, medicine, Influenza A virus, Animals, Humans, ddc:576, Influenza A Virus, H1N1 Subtype/genetics/isolation & purification, Influenza in Birds/virology, Phylogeny, Multiple sequence alignment, Database, Phylogenetic tree, biology, Sequence Alignment/statistics & numerical data, Orthomyxoviridae/genetics/isolation & purification, biology.organism_classification, Influenza A virus subtype H5N1, Influenza, Human/virology, Influenza in Birds, GenBank, Influenza A Virus, H1N1 Subtype/genetics, Influenza A Virus, H1N1 Subtype/isolation & purification, Orthomyxoviridae/genetics, Orthomyxoviridae/isolation & purification, Orthomyxoviridae Infections/virology, Original Article, General Agricultural and Biological Sciences, Sequence Alignment, computer, Information Systems |
| الوصف: | Although research on influenza lasted for more than 100 years, it is still one of the most prominent diseases causing half a million human deaths every year. With the recent observation of new highly pathogenic H5N1 and H7N7 strains, and the appearance of the influenza pandemic caused by the H1N1 swine-like lineage, a collaborative effort to share observations on the evolution of this virus in both animals and humans has been established. The OpenFlu database (OpenFluDB) is a part of this collaborative effort. It contains genomic and protein sequences, as well as epidemiological data from more than 27,000 isolates. The isolate annotations include virus type, host, geographical location and experimentally tested antiviral resistance. Putative enhanced pathogenicity as well as human adaptation propensity are computed from protein sequences. Each virus isolate can be associated with the laboratories that collected, sequenced and submitted it. Several analysis tools including multiple sequence alignment, phylogenetic analysis and sequence similarity maps enable rapid and efficient mining. The contents of OpenFluDB are supplied by direct user submission, as well as by a daily automatic procedure importing data from public repositories. Additionally, a simple mechanism facilitates the export of OpenFluDB records to GenBank. This resource has been successfully used to rapidly and widely distribute the sequences collected during the recent human swine flu outbreak and also as an exchange platform during the vaccine selection procedure. Database URL: http://openflu.vital-it.ch. |
| وصف الملف: | application/pdf |
| تدمد: | 1758-0463 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6396b95b92373df6e58716b881b186 https://doi.org/10.1093/database/baq004 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0e6396b95b92373df6e58716b881b186 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17580463 |
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