Estrogen receptor α geneESR1amplification may predict endocrine therapy responsiveness in breast cancer patients
| العنوان: | Estrogen receptor α geneESR1amplification may predict endocrine therapy responsiveness in breast cancer patients |
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| المؤلفون: | Masahiro Nakano, Zhenhuan Zhang, Teru Kawazoe, Saori Tomita, Hirotaka Iwase, Mutsuko Ibusuki, Yutaka Yamamoto |
| المصدر: | Cancer Science. 100:1012-1017 |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Cancer Research, medicine.medical_specialty, Gene Dosage, Estrogen receptor, Breast Neoplasms, Biology, Polymerase Chain Reaction, Disease-Free Survival, Ribonuclease P, Breast cancer, Estrogen Receptor Modulators, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Gene duplication, medicine, Humans, Gene, Menstrual Cycle, Aged, DNA Primers, Aged, 80 and over, Aromatase Inhibitors, Estrogen Receptor alpha, Gene Amplification, Cancer, General Medicine, Middle Aged, medicine.disease, Gene Expression Regulation, Neoplastic, body regions, Endocrinology, Real-time polymerase chain reaction, Oncology, Cancer research, Female, Breast disease, Estrogen receptor alpha |
| الوصف: | Estrogen receptor (ER) α plays a crucial role in normal breast development and has also been linked to mammary carcinogenesis and clinical outcome in breast cancer patients. However, the molecular mechanisms controlling the expression of ERα are as yet not fully understood. Gene amplification is one of the important factors regulating protein expression. Recent studies on the amplification of the ESR1 gene, which encodes ERα, have presented conflicting data. Using fluorescence in situ hybridization and real-time quantitative polymerase chain reaction analysis, we examined the ESR1 status in a series of breast cancer tissues and analyzed its clinical importance. ESR1 gene amplification and gain were found in 22.6 and 11.3% of samples, respectively, as determined by three-dimensional fluorescence in situ hybridization assay. Moreover, ESR1 amplification and amplification plus gain were significantly negatively correlated with tumor size, number of positive lymph nodes, negative ERα, and positive human epidermal growth factor receptor 2 status. It has also been shown that ESR1 amplification strongly correlates with higher expression levels of ER protein and that patients with ESR1 amplification in their tumors apparently experience longer disease-free survival than those without. Our data suggest that ESR1 amplification might prove to be helpful in selecting patients who may potentially benefit from endocrine therapy. (Cancer Sci 2009; 100: 1012–1017) |
| تدمد: | 1349-7006 1347-9032 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e77c6613a2b4a059f147e99a23eaee1 https://doi.org/10.1111/j.1349-7006.2009.01145.x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0e77c6613a2b4a059f147e99a23eaee1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497006 13479032 |
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