The Role of Secreted Frizzled-related Protein-1 in Allergic Asthma
| العنوان: | The Role of Secreted Frizzled-related Protein-1 in Allergic Asthma |
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| المؤلفون: | Nooralam Rai, Emilio Arteaga-Solis, Monica Goldklang, Tina Zelonina, Jeanine D’Armiento |
| المصدر: | Am J Respir Cell Mol Biol |
| بيانات النشر: | American Thoracic Society, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Inflammation, Pulmonary and Respiratory Medicine, Pyroglyphidae, Clinical Biochemistry, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Cell Biology, Asthma, Disease Models, Animal, Mice, Hypersensitivity, Animals, Humans, Bronchoalveolar Lavage Fluid, Molecular Biology, Original Research |
| الوصف: | Although allergic asthma is a highly prevalent chronic inflammatory condition, the underlying pathogenesis driving T-helper cell type 2 inflammation is not well understood. Wnt/β-catenin signaling has been implicated, but the influence of individual members of the pathway is not clear. We hypothesized that SFRP-1 (secreted frizzled-related protein-1), a Wnt signaling modulator, plays an important role in the development of allergic inflammation in asthma. Using an in vivo house dust mite asthma model, SFRP-1(−/−) mice were sensitized, and their BAL fluid was collected to evaluate airway inflammation. SFRP-1(−/−) mice exhibited less inflammation with reduced cellular infiltration and concentration of IL-5 in bronchoalveolar lavage fluid compared with wild-type (WT) mice. Similar findings were observed in WT mice treated with SFRP-1 inhibitor, WAY316606. Alveolar macrophages from sensitized SFRP-1(−/−) mice demonstrated reduced alternative polarization compared with WT, indicating that macrophages could mediate the alteration in inflammation seen in these mice. These findings suggest that SFRP-1 is an important potentiator of asthmatic airway inflammation. |
| تدمد: | 1535-4989 1044-1549 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9bc8b49ce60fc2a8c4c06aa89230f7 https://doi.org/10.1165/rcmb.2020-0314oc |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0e9bc8b49ce60fc2a8c4c06aa89230f7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354989 10441549 |
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