Meta-Analysis of the QTLome of Fusarium Head Blight Resistance in Bread Wheat: Refining the Current Puzzle
| العنوان: | Meta-Analysis of the QTLome of Fusarium Head Blight Resistance in Bread Wheat: Refining the Current Puzzle |
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| المؤلفون: | Camila Pegoraro, Railson Schreinert dos Santos, Vianei Rother, Luciano Carlos da Maia, Daniel da Rosa Farias, Eduardo Venske, Antonio Costa de Oliveira |
| المصدر: | Frontiers in Plant Science, Vol 10 (2019) Frontiers in Plant Science |
| بيانات النشر: | Frontiers Media SA, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, Fusarium, Candidate gene, molecular markers, Plant Science, Computational biology, lcsh:Plant culture, Quantitative trait locus, 01 natural sciences, Genome, meta-QTL, Transcriptome, 03 medical and health sciences, Head blight, lcsh:SB1-1110, genome, Gene, biology, food and beverages, bioinformatics, biology.organism_classification, genetic architecture, Genetic architecture, 030104 developmental biology, genetic maps, Systematic Review, transcriptome, 010606 plant biology & botany |
| الوصف: | Background: Fusarium Head Blight (FHB) is a worldwide devastating disease of bread wheat (Triticum aestivum L.). Genetic resistance is the most effective way to control FHB and many QTL related to this trait have been mapped on the wheat genetic map. This information, however, must be refined to be more efficiently used in breeding programs and for the advance of the basic research. The objective of the present study was to in-depth analyze the QTLome of FHB resistance in bread wheat, further integrating genetic, genomic, and transcriptomic data, aiming to find candidate genes. Methods: An exhaustive bibliographic review on 76 scientific papers was carried out collecting information about QTL related to FHB resistance mapped on bread wheat. A dense genetic consensus map with 572,862 loci was generated for QTL projection. Meta-analysis could be performed on 323 QTL. Candidate gene mining was carried out within the most refined loci, containing genes that were cross-validated with publicly available transcriptional expression data of wheat under Fusarium infection. Most highlighted genes were investigated for protein evidence. Results: A total of 556 QTL were found in the literature, distributed on all sub-genomes and chromosomes of wheat. Meta-analysis generated 65 meta-QTL, and this refinement allows one to find markers more tightly linked to these regions. Candidate gene mining within the most refined meta-QTL, meta-QTL 1/chr. 3B, harvested 324 genes and transcriptional data cross-validated 10 of these genes, as responsive to FHB. One is of these genes encodes a Glycosiltransferase and the other encodes for a Cytochrome P450, and these such proteins have already been verified as being responsible for FHB resistance, but the remaining eight genes still have to be further studied, as promising loci for breeding. Conclusions: The QTLome of FHB resistance in wheat was successfully assembled and a refinement in terms of number and length of loci was obtained. The integration of the QTLome with genomic and transcriptomic data has allowed for the discovery of promising candidate genes for use in breeding programs. |
| تدمد: | 1664-462X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eae0f8b1d233816d443f5c5103514bc https://doi.org/10.3389/fpls.2019.00727 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0eae0f8b1d233816d443f5c5103514bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1664462X |
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