Design and System Evaluation of a Dual-Panel Portable PET (DP-PET)
| العنوان: | Design and System Evaluation of a Dual-Panel Portable PET (DP-PET) |
|---|---|
| المؤلفون: | Lingzhi Hu, Adam Chandler, Xin Chen, Tuoyu Cao, Qun Chen, Zheng Jiaxu, Xu Chu, Xia Xinyuan, Zhang Shuangyue, Tianyi Zeng, Beien Wang |
| المصدر: | EJNMMI Physics, Vol 8, Iss 1, Pp 1-16 (2021) EJNMMI Physics |
| بيانات النشر: | Research Square Platform LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Scanner, Radiation, Potable PET, Image quality, Computer science, MR-compatible PET, Detector, Biomedical Engineering, R895-920, System performance, Imaging phantom, Medical physics. Medical radiology. Nuclear medicine, Silicon photomultiplier, Interference (communication), PET insert, Radiology, Nuclear Medicine and imaging, Sensitivity (control systems), Instrumentation, Image resolution, Original Research, Biomedical engineering |
| الوصف: | Background Integrated whole-body PET/MR technology continues to mature and is now extensively used in clinical settings. However, due to the special design architecture, integrated whole-body PET/MR comes with a few inherent limitations. Firstly, whole-body PET/MR lacks sensitivity and resolution for focused organs. Secondly, broader clinical access of integrated PET/MR has been significantly restricted due to its prohibitively high cost. The MR-compatible PET insert is an independent and removable PET scanner which can be placed within an MRI bore. However, the mobility and configurability of all existing MR-compatible PET insert prototypes remain limited. Methods An MR-compatible portable PET insert prototype, dual-panel portable PET (DP-PET), has been developed for simultaneous PET/MR imaging. Using SiPM, digital readout electronics, novel carbon fiber shielding, phase-change cooling, and MRI compatible battery power, DP-PET was designed to achieve high-sensitivity and high-resolution with compatibility with a clinical 3-T MRI scanner. A GPU-based reconstruction method with resolution modeling (RM) has been developed for the DP-PET reconstruction. We evaluated the system performance on PET resolution, sensitivity, image quality, and the PET/MR interference. Results The initial results reveal that the DP-PET prototype worked as expected in the MRI bore and caused minimal compromise to the MRI image quality. The PET performance was measured to show a spatial resolution ≤ 2.5 mm (parallel to the detector panels), maximum sensitivity = 3.6% at the center of FOV, and energy resolution = 12.43%. MR pulsing introduces less than 2% variation to the PET performance measurement results. Conclusions We developed a MR-compatible PET insert prototype and performed several studies to begin to characterize the performance of the proposed DP-PET. The results showed that the proposed DP-PET performed well in the MRI bore and would cause little influence on the MRI images. The Derenzo phantom test showed that the proposed reconstruction method could obtain high-quality images using DP-PET. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0dfcf1026ef3f3061ba901a0fa9d04 https://doi.org/10.21203/rs.3.rs-300103/v1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0f0dfcf1026ef3f3061ba901a0fa9d04 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |