Activity of quinolones against viridans group streptococci isolated from blood cultures of patients with haematological malignancy
| العنوان: | Activity of quinolones against viridans group streptococci isolated from blood cultures of patients with haematological malignancy |
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| المؤلفون: | Hannah T. Armitage, Paul H. M. McWhinney, K. G. Kerr |
| المصدر: | Supportive Care in Cancer. 7:28-30 |
| بيانات النشر: | Springer Science and Business Media LLC, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Adult, Neutropenia, Fleroxacin, medicine.drug_class, Antibiotics, Bacteremia, medicine.disease_cause, Microbiology, chemistry.chemical_compound, Anti-Infective Agents, Ciprofloxacin, Risk Factors, Streptococcal Infections, medicine, Humans, Naphthyridines, Streptococcus, business.industry, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Antimicrobial, medicine.disease, Trovafloxacin, Oncology, chemistry, Hematologic Neoplasms, business, Clinafloxacin, Fluoroquinolones, medicine.drug |
| الوصف: | Use of fluoroquinolones for antimicrobial prophylaxis during neutropenia is often cited as a significant predisposing factor for viridans group streptococcus (VGS) bacteraemia. Newer compounds in this class are reputed to have enhanced activity against Gram-positive bacteria, and we determined the minimal inhibitory concentrations (MICs) for ciprofloxacin and three of the newer compounds: trovafloxacin, fleroxacin and clinafloxacin, against 44 isolates of VGS. On a gravimetric basis, clinafloxacin was most active (MIC90 0.19 mg/l), whereas ciprofloxacin and fleroxacin were the least active (both MIC90 16 mg/l). Clinafloxacin warrants further study as an agent of prophylaxis against bacterial infection in neutropenic patients. |
| تدمد: | 1433-7339 0941-4355 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1a49e835bc2627b462193894bbf0fd https://doi.org/10.1007/s005200050219 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....0f1a49e835bc2627b462193894bbf0fd |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14337339 09414355 |
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