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The PPM1F gene moderates the association between PTSD and cortical thickness

التفاصيل البيبلوغرافية
العنوان: The PPM1F gene moderates the association between PTSD and cortical thickness
المؤلفون: Filomene G. Morrison, David H. Salat, Erika J. Wolf, Danielle R. Sullivan, Jennifer R. Fonda, Annjanette Stone, Catherine Fortier, Steven A. Schichman, Regina E. McGlinchey, William P. Milberg, Mark W. Logue, Mark W. Miller
المصدر: J Affect Disord
بيانات النشر: Elsevier BV, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Adult, Male, Oncology, medicine.medical_specialty, Genotype, Prefrontal Cortex, Single-nucleotide polymorphism, Serotonergic, Polymorphism, Single Nucleotide, Article, Stress Disorders, Post-Traumatic, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Phosphoprotein Phosphatases, medicine, Humans, Prefrontal cortex, Association (psychology), Gene, Depression (differential diagnoses), Veterans, PPM1F gene, Depression, business.industry, Small sample, Middle Aged, Magnetic Resonance Imaging, 030227 psychiatry, Psychiatry and Mental health, Clinical Psychology, Female, Atrophy, business, 030217 neurology & neurosurgery
الوصف: BACKGROUND: Evidence suggests that single nucleotide polymorphisms (SNPs) in genes involved in serotonergic signaling and stress response pathways moderate associations between PTSD and cortical thickness. This study examined a genetic regulator of these pathways, the PPM1F gene, which has also been implicated in mechanisms of stress responding and is differentially expressed in individuals with comorbid PTSD and depression compared to controls. METHODS: Drawing from a sample of 240 white non-Hispanic trauma-exposed veterans, we tested 18 SNPs spanning the PPM1F gene for association with PTSD and cortical thickness. RESULTS: Analyses revealed six PPM1F SNPs that moderated associations between PTSD symptom severity and cortical thickness of bilateral superior frontal and orbitofrontal regions as well as the right pars triangularis (all corrected p’s
تدمد: 0165-0327
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2891c56b23d0a8309196d8af19ed00
https://doi.org/10.1016/j.jad.2019.08.055
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....0f2891c56b23d0a8309196d8af19ed00
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01650327