Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions
| العنوان: | Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions |
|---|---|
| المؤلفون: | Anthony McGregor, Yutaka Kosaki, David J. Sanderson, Steven L. Poulter |
| المصدر: | Brain and neuroscience advances, 2020, Vol.4 [Peer Reviewed Journal] Brain and Neuroscience Advances |
| بيانات النشر: | Sage, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | geometry, Cognitive map, genetic structures, Computer science, hippocampus, General Neuroscience, dorsolateral striatum, 05 social sciences, Cognitive neuroscience of visual object recognition, Hippocampus, Geometry, Context (language use), Dorsolateral, Hippocampal formation, cognitive map, 050105 experimental psychology, context, Spontaneous object recognition, 0501 psychology and cognitive sciences, 050102 behavioral science & comparative psychology, Neurology (clinical), Habituation, Recognition memory, Research Paper |
| الوصف: | We examined the role of the hippocampus and the dorsolateral striatum in the representation of environmental geometry using a spontaneous object recognition procedure. Rats were placed in a kite-shaped arena and allowed to explore two distinctive objects in each of the right-angled corners. In a different room, rats were then placed into a rectangular arena with two identical copies of one of the two objects from the exploration phase, one in each of the two adjacent right-angled corners that were separated by a long wall. Time spent exploring these two objects was recorded as a measure of recognition memory. Since both objects were in different locations with respect to the room (different between exploration and test phases) and the global geometry (also different between exploration and test phases), differential exploration of the objects must be a result of initial habituation to the object relative to its local geometric context. The results indicated an impairment in processing the local geometric features of the environment for both hippocampus and dorsolateral striatum lesioned rats compared with sham-operated controls, though a control experiment showed these rats were unimpaired in a standard object recognition task. The dorsolateral striatum has previously been implicated in egocentric route-learning, but the results indicate an unexpected role for the dorsolateral striatum in processing the spatial layout of the environment. The results provide the first evidence that lesions to the hippocampus and dorsolateral striatum impair spontaneous encoding of local environmental geometric features. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f489200cefb5c6c3d326a665901c70c http://dro.dur.ac.uk/31931/1/31931.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0f489200cefb5c6c3d326a665901c70c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |