Interstitial lung disease progression after genomic usual interstitial pneumonia testing
| العنوان: | Interstitial lung disease progression after genomic usual interstitial pneumonia testing |
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| المؤلفون: | Sachin Chaudhary, S. Sam Weigt, Manuel L. Ribeiro Neto, Bryan S. Benn, Janelle Vu Pugashetti, Rebecca Keith, Arista Chand, Scott Oh, Fayez Kheir, Vijaya Ramalingam, Joshua J. Solomon, Richart Harper, Joseph A. Lasky, Justin M. Oldham |
| المصدر: | Eur Respir J |
| بيانات النشر: | European Respiratory Society (ERS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Article |
| الوصف: | BackgroundA genomic classifier for usual interstitial pneumonia (gUIP) has been shown to predict histological UIP with high specificity, increasing diagnostic confidence for idiopathic pulmonary fibrosis (IPF). Whether those with positive gUIP classification exhibit a progressive, IPF-like phenotype remains unknown.MethodsA pooled, retrospective analysis of patients who underwent clinically indicated diagnostic bronchoscopy with gUIP testing at seven academic medical centres across the USA was performed. We assessed the association between gUIP classification and 18-month progression-free survival (PFS) using Cox proportional hazards regression. PFS was defined as the time from gUIP testing to death from any cause, lung transplant, ≥10% relative decline in forced vital capacity (FVC) or censoring at the time of last available FVC measure. Longitudinal change in FVC was then compared between gUIP classification groups using a joint regression model.ResultsOf 238 consecutive patients who underwent gUIP testing, 192 had available follow-up data and were included in the analysis, including 104 with positive gUIP classification and 88 with negative classification. In multivariable analysis, positive gUIP classification was associated with reduced PFS (hazard ratio 1.58, 95% CI 0.86–2.92; p=0.14), but this did not reach statistical significance. Mean annual change in FVC was −101.8 mL (95% CI −142.7– −60.9 mL; pConclusionsgUIP classification was not associated with differential rates of PFS or longitudinal FVC decline in a multicentre interstitial lung disease cohort undergoing bronchoscopy as part of the diagnostic evaluation. |
| تدمد: | 1399-3003 0903-1936 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f59548c9129b870a45ed609bbcc9265 https://doi.org/10.1183/13993003.01245-2022 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0f59548c9129b870a45ed609bbcc9265 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13993003 09031936 |
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