Familial homozygous hypercholesterolemia in children: early diagnosis and treatment
| العنوان: | Familial homozygous hypercholesterolemia in children: early diagnosis and treatment |
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| المؤلفون: | I. V. Leontyeva |
| المصدر: | Rossijskij Vestnik Perinatologii i Pediatrii, Vol 66, Iss 4, Pp 118-128 (2021) |
| بيانات النشر: | The National Academy of Pediatric Science and Innovation, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Apolipoprotein B, Disease, Delayed diagnosis, Pediatrics, RJ1-570, children, Internal medicine, medicine, Myocardial infarction, Familial homozygous hypercholesterolemia, genetic aspects, lipid-lowering therapy, biology, business.industry, PCSK9, medicine.disease, Coronary arteries, medicine.anatomical_structure, diagnostic criteria, Pediatrics, Perinatology and Child Health, LDL receptor, biology.protein, lipids (amino acids, peptides, and proteins), familial homozygous hypercholesterolemia, business |
| الوصف: | Familial homozygous hypercholesterolemia is a rare life-threatening disease, the prevalence is 1: 160,000-1: 320,000. The main manifestation of the disease is an extremely high level of low-density lipoprotein cholesterol (more than 13 mmol / l), which causes early atherosclerotic vascular lesions, including coronary arteries, starting from the first decade of life, and can lead to myocardial infarction in childhood. Familial homozygous hypercholesterolemia remains a little-known disease in the clinical practice of the pediatrician; it leads to delayed diagnosis and late initiation of therapy. The most common cause of the disease is mutations in the LDLR (90%) gene, less often in the APOB (5–10%), PCSK9 (1%), LDLRAP1 (1%) genes. The article presents the criteria for the diagnosis of familial homozygous hypercholesterolemia in children. The authors discuss clinical manifestations on the skin and at the level of the cardiovascular system, eyes. They present the strategy of management and the possibilities of treating patients. The paper presents the indications for the appointment and the effectiveness of statins, ezetrol, monoclonal antibodies to PCSK9, apheresis for the treatment of the disease. It discusses prospects for further therapy. |
| تدمد: | 2500-2228 1027-4065 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f88fe731896ae8ee5619eb4a7397c19 https://doi.org/10.21508/1027-4065-2021-66-4-118-128 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0f88fe731896ae8ee5619eb4a7397c19 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25002228 10274065 |
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