Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes
| العنوان: | Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes |
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| المؤلفون: | Bart Jan Kullberg, Evangelos J. Giamarellos-Bourboulis, Daniela C. Ifrim, Liesbeth Jacobs, Jessica Quintin, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, Hendrik G. Stunnenberg, Jos W. M. van der Meer, Sadia Saeed, Joost H.A. Martens, Ramnik J. Xavier, Colin Logie, Trees Jansen |
| المساهمون: | Radboud University Medical Center [Nijmegen], Radboud university [Nijmegen], National and Kapodistrian University of Athens (NKUA), Jena University Hospital [Jena], University Medical Center Groningen [Groningen] (UMCG), Massachusetts General Hospital [Boston], Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI) |
| المصدر: | Cell Host & Microbe, 12, 2, pp. 223-232 Cell Host and Microbe Cell Host and Microbe, Elsevier, 2012, 12 (2), pp.223-232. ⟨10.1016/j.chom.2012.06.006⟩ Cell Host & Microbe, 12, 223-232 Cell Host & Microbe, 12(2), 223-232. CELL PRESS |
| بيانات النشر: | CELL PRESS, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Cancer Research, POLARIZATION, Genetics and epigenetic pathways of disease [NCMLS 6], [SDV]Life Sciences [q-bio], MESH: Monocytes, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Monocytes, ACTIVATION, Mice, NATURAL-KILLER-CELLS, 0302 clinical medicine, Candida albicans, IMMUNE-RESPONSE, MESH: Animals, TRANSCRIPTION, EPIGENETIC REGULATION, Cells, Cultured, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, 0303 health sciences, MESH: Cytokines, IMMUNOSUPPRESSION, Candidiasis, Health aging / healthy living Pathogenesis and modulation of inflammation [IGMD 5], Corpus albicans, MESH: Candidiasis, CROHNS-DISEASE, 3. Good health, Pathogenesis and modulation of inflammation [N4i 1], medicine.anatomical_structure, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, 030220 oncology & carcinogenesis, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Reprogramming, MESH: Cells, Cultured, Biology, Invasive mycoses and compromised host Infection and autoimmunity [N4i 2], Microbiology, DENDRITIC CELLS, Article, 03 medical and health sciences, Immune system, Immunity, MESH: Mice, Inbred C57BL, Virology, Immunology and Microbiology(all), medicine, Animals, Humans, Lectins, C-Type, MESH: Mice, Molecular Biology, B cell, 030304 developmental biology, Innate immune system, MESH: Humans, Monocyte, MESH: Candida albicans, MEMORY, Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1], biology.organism_classification, Mice, Inbred C57BL, Proto-Oncogene Proteins c-raf, Immunology, MESH: Proto-Oncogene Proteins c-raf, Parasitology, MESH: Female, MESH: Lectins, C-Type |
| الوصف: | Item does not contain fulltext Immunological memory in vertebrates is often exclusively attributed to T and B cell function. Recently it was proposed that the enhanced and sustained innate immune responses following initial infectious exposure may also afford protection against reinfection. Testing this concept of "trained immunity," we show that mice lacking functional T and B lymphocytes are protected against reinfection with Candida albicans in a monocyte-dependent manner. C. albicans and fungal cell wall beta-glucans induced functional reprogramming of monocytes, leading to enhanced cytokine production in vivo and in vitro. The training required the beta-glucan receptor dectin-1 and the noncanonical Raf-1 pathway. Monocyte training by beta-glucans was associated with stable changes in histone trimethylation at H3K4, which suggests the involvement of epigenetic mechanisms in this phenomenon. The functional reprogramming of monocytes, reminiscent of similar NK cell properties, supports the concept of "trained immunity" and may be employed for the design of improved vaccination strategies. |
| اللغة: | English |
| تدمد: | 1934-6069 1931-3128 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb213d471139242048ce17e5457d053 https://doi.org/10.1016/j.chom.2012.06.006 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0fb213d471139242048ce17e5457d053 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19346069 19313128 |
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