ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation
| العنوان: | ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation |
|---|---|
| المؤلفون: | Naoki Hisamoto, Kana Osaki, Rio Ikuta, Fumihiko Okumura, Nodoka Oki, Yuha Fujiki, Takumi Kamura, Taichi Hara, Kunio Nakatsukasa, Shun Hamada |
| المصدر: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
| بيانات النشر: | Nature Publishing Group UK, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | MAPK/ERK pathway, MAP Kinase Signaling System, Science, Ubiquitin-Protein Ligases, Stem-cell differentiation, CDC42, Muscle Development, p38 Mitogen-Activated Protein Kinases, Article, Cell Line, Ubiquitin, Cell Line, Tumor, Animals, Humans, Protein kinase A, Multidisciplinary, biology, Chemistry, Myogenesis, Cell Differentiation, Ubiquitin ligase, Cell biology, HEK293 Cells, Proteolysis, biology.protein, Medicine, K562 Cells, C2C12, Cell Adhesion Molecules, Cullin, Cell signalling, Post-translational modifications, Protein Binding |
| الوصف: | Cell adhesion molecule-related/downregulated by oncogenes (Cdon) is a cell-surface receptor that mediates cell–cell interactions and positively regulates myogenesis. The cytoplasmic region of Cdon interacts with other proteins to form a Cdon/JLP/Bnip-2/CDC42 complex that activates p38 mitogen-activated protein kinase (MAPK) and induces myogenesis. However, Cdon complex may include other proteins during myogenesis. In this study, we found that Cullin 2-interacting protein zinc finger SWIM type containing 8 (ZSWIM8) ubiquitin ligase is induced during C2C12 differentiation and is included in the Cdon complex. We knocked-down Zswim8 in C2C12 cells to determine the effect of ZSWIM8 on differentiation. However, we detected neither ZSWIM8-dependent ubiquitination nor the degradation of Bnip2, Cdon, or JLP. In contrast, ZSWIM8 knockdown accelerated C2C12 differentiation. These results suggest that ZSWIM8 is a Cdon complex-included myogenic protein that prevents C2C12 differentiation without affecting the stability of Bnip2, Cdon, and JLP. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd8f1bfafcb92e38b427dd954e08655 http://europepmc.org/articles/PMC8536758 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0fd8f1bfafcb92e38b427dd954e08655 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20452322 |
|---|