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Application of noninvasive signal-averaged electrocardiogram analysis in predicting the requirement of epicardial ablation in patients with arrhythmogenic right ventricular cardiomyopathy

التفاصيل البيبلوغرافية
العنوان: Application of noninvasive signal-averaged electrocardiogram analysis in predicting the requirement of epicardial ablation in patients with arrhythmogenic right ventricular cardiomyopathy
المؤلفون: Cheng I. Wu, Chye Gen Chin, Ching Han Liu, Li Wei Lo, Yu Feng Hu, Ching Yao Chou, Ta Chuan Tuan, Shih Ann Chen, Fa Po Chung, Tze Fan Chao, Chih Min Liu, Isaiah C. Lugtu, Chin Yu Lin, Shih Lin Chang, Ling Kuo, Chun Chao Chen, Yenn Jiang Lin, Shin Huei Liu, Vern Hsen Tan, Jennifer Jeanne B. Vicera, Wen Han Cheng, Ting Yung Chang, Jo Nan Liao
المصدر: Heart rhythm. 17(4)
سنة النشر: 2019
مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Heart Ventricles, 030204 cardiovascular system & hematology, Right ventricular cardiomyopathy, 03 medical and health sciences, Electrocardiography, 0302 clinical medicine, Heart Conduction System, Heart Rate, Predictive Value of Tests, Physiology (medical), Internal medicine, medicine, Humans, 030212 general & internal medicine, Endocardium, Arrhythmogenic Right Ventricular Dysplasia, Retrospective Studies, Surrogate endpoint, business.industry, Odds ratio, Middle Aged, Ablation, Confidence interval, Signal-averaged electrocardiogram, Cardiology, Catheter Ablation, Ventricular Function, Right, Female, Abnormality, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
الوصف: Signal-averaged electrocardiogram (SAECG) provides not only diagnostic information but also the prognostic implication of ablation in arrhythmogenic right ventricular cardiomyopathy (ARVC).This study aimed to validate the role of SAECG in identifying arrhythmogenic substrates requiring an epicardial approach in ARVC.Ninety-one patients with a definite diagnosis of ARVC who underwent successful ablation for drug-refractory ventricular arrhythmia were enrolled and classified into 2 groups: group 1 who underwent successful ablation at the endocardium only and group 2 who underwent successful ablation requiring an additional epicardial approach. The baseline characteristics of patients and SAECG parameters were obtained for analysis.Male predominance, worse right ventricular (RV) function, higher incidence of syncope, and depolarization abnormality were observed in group 2. Moreover, the number of abnormal SAECG criteria was higher in group 2 than in group 1. After a multivariate analysis, the independent predictors of the requirement of epicardial ablation included the number of abnormal SAECG criteria (odds ratio 2.8, 95% confidence interval 1.4-5.4; P = .003) and presence of syncope (odds ratio 11.7; 95% confidence interval 2.7-50.4; P = .001). In addition, ≥2 abnormal SAECG criteria were associated with larger RV endocardial unipolar low-voltage zone (P.001), larger RV endocardial/epicardial bipolar low-voltage zone/scar (P.05), and longer RV endocardial/epicardial total activation time (P.001 and P = .004, respectively).The number of abnormal SAECG criteria was correlated with the extent of diseased epicardial substrates and could be a potential surrogate marker for predicting the requirement of epicardial ablation in patients with ARVC.
تدمد: 1556-3871
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10388dc6e2c68be88f215003fa80c7ac
https://pubmed.ncbi.nlm.nih.gov/31756530
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....10388dc6e2c68be88f215003fa80c7ac
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15563871