Development of Laser-Structured Liquid-Infused Titanium with Strong Biofilm-Repellent Properties
| العنوان: | Development of Laser-Structured Liquid-Infused Titanium with Strong Biofilm-Repellent Properties |
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| المؤلفون: | Tobias Ehmke, Elena Fadeeva, Nico S. Stumpp, Meike Stiesch, Joern Schaeske, Katharina Doll, Boris N. Chichkov, Alexander Heisterkamp, Andreas Winkel |
| المصدر: | ACS Applied Materials & Interfaces. 9:9359-9368 |
| بيانات النشر: | American Chemical Society (ACS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Modern medicine, Materials science, Medical device, Surface Properties, chemistry.chemical_element, Nanotechnology, 02 engineering and technology, Bacterial Adhesion, law.invention, Pulsed laser ablation, 03 medical and health sciences, Bacterial colonization, law, Humans, General Materials Science, Titanium, Resistance development, Biofilm, 021001 nanoscience & nanotechnology, Laser, 030104 developmental biology, chemistry, Biofilms, 0210 nano-technology |
| الوصف: | Medical implants are commonly used in modern medicine but still harbor the risk of microbial infections caused by bacterial biofilms. As their retrospective treatment is difficult, there is a need for biomedical materials that inhibit bacterial colonization from the start without using antibacterial agents, as these can promote resistance development. The promising concept of slippery liquid-infused porous surfaces (SLIPS) possesses enormous potential for this purpose. In the present study, this principle was applied to titanium, a common material in implantology, and its biofilm-repellent properties were demonstrated. To simplify prospective approval of the medical device and to avoid chemical contamination, surface structuring was performed by ultrashort pulsed laser ablation. Four different structures (hierarchical micro- and nanosized spikes, microsized grooves, nanosized ripples, and unstructured surfaces) and five infusing perfluoropolyethers of different viscosities were screened; the best results were obtained with the biomimetic, hierarchical spike structure combined with lubricants of medium viscosities (20-60 cSt at 37 °C, 143 AZ, and GPL 104). The surfaces exhibited extremely low contact angle hysteresis, as is typical for liquid-infused materials and a reliable 100-fold reduction of human oral pathogen Streptococcus oralis biofilms. This characteristic was maintained after exposure to shear forces and gravity. The titanium SLIPS also inhibited adherence of human fibroblasts and osteoblasts. Toxicity tests supported the explanation that solely the surface's repellent properties are responsible for the vigorous prevention of the adhesion of bacteria and cells. This use of physically structured and liquid-infused titanium to avoid bioadhesion should support the prevention of bacterial implant-associated infections without the use of antibacterial agents. |
| تدمد: | 1944-8252 1944-8244 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1054a44fcbd438afd841fc94eed708e6 https://doi.org/10.1021/acsami.6b16159 |
| رقم الأكسشن: | edsair.doi.dedup.....1054a44fcbd438afd841fc94eed708e6 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 19448252 19448244 |
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