Zwitterionic 3D‐Printed Non‐Immunogenic Stealth Microrobots
| العنوان: | Zwitterionic 3D‐Printed Non‐Immunogenic Stealth Microrobots |
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| المؤلفون: | Metin Sitti, Abdon Pena-Francesch, Ugur Bozuyuk, Devin Sheehan, Oncay Yasa, Salvador Borrós, Pol Cabanach |
| المساهمون: | Sitti, Metin (ORCID 0000-0001-8249-3854 & YÖK ID 297104), Cabanach, Poi, Pena-Francesch, Abdon, Sheehan, Devin, Bozüyük, Uğur, Yaşa, Öncay, Borros, Salvador, School of Medicine, College of Engineering, Department of Mechanical Engineering |
| المصدر: | Advanced materials (Deerfield Beach, Fla.) Advanced Materials, 32 (42) Advanced Materials |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | zwitterionic materials, 3d printed, Materials science, two‐photon polymerization, Surface Properties, Nanotechnology, 02 engineering and technology, non-immunogenic properties, 010402 general chemistry, 01 natural sciences, Microprinting, Article, Macrophages, Non-immunogenic properties, Stealth microrobots, Two-photon polymerization, Zwitterionic materials, Materials Testing, General Materials Science, Magnetic actuation, Immune Evasion, Mechanical Phenomena, non‐immunogenic properties, macrophages, stealth microrobots, Mechanical Engineering, Chemistry, Science and technology, Physics, Hydrogels, Robotics, 021001 nanoscience & nanotechnology, Biocompatible material, 0104 chemical sciences, two-photon polymerization, Mechanics of Materials, Printing, Three-Dimensional, Drug delivery, Microtechnology, 0210 nano-technology |
| الوصف: | Microrobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a natural protection mechanism against foreign threats. Here, non-immunogenic stealth zwitterionic microrobots that avoid recognition from immune cells are introduced. Fully zwitterionic photoresists are developed for two-photon polymerization 3D microprinting of hydrogel microrobots with ample functionalization: tunable mechanical properties, anti-biofouling and non-immunogenic properties, functionalization for magnetic actuation, encapsulation of biomolecules, and surface functionalization for drug delivery. Stealth microrobots avoid detection by macrophage cells of the innate immune system after exhaustive inspection (>90 hours), which has not been achieved in any microrobotic platform to date. These versatile zwitterionic materials eliminate a major roadblock in the development of biocompatible microrobots, and will serve as a toolbox of non-immunogenic materials for medical microrobot and other device technologies for bioengineering and biomedical applications. Advanced Materials, 32 (42) ISSN:0935-9648 ISSN:1521-4095 |
| وصف الملف: | application/application/pdf; pdf |
| تدمد: | 1521-4095 0935-9648 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106468bccfc5aa7899504873f954d723 https://doi.org/10.1002/adma.202003013 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....106468bccfc5aa7899504873f954d723 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15214095 09359648 |
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