Interferon-b Inhibits Liver Metastases from Murine Colon 26 Carcinoma and its Highly Metastatic Variant
| العنوان: | Interferon-b Inhibits Liver Metastases from Murine Colon 26 Carcinoma and its Highly Metastatic Variant |
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| المؤلفون: | Hiroki Shomura, Yoshie Une, Jun Nishihira, Tsuyoshi Fukushima, Takahiro Oshima, Satoru Todo, Shigechika Kohashi, Masao Kondo, Sun Bairun, Yuji Sato |
| المصدر: | Surgery Today. 37:474-481 |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Angiogenesis, Antineoplastic Agents, Mice, Liver Neoplasms, Experimental, Interferon β, Surgical oncology, Cell Line, Tumor, Carcinoma, Animals, Medicine, Cell Proliferation, Mice, Inbred BALB C, business.industry, Cell growth, General Medicine, medicine.disease, Recombinant Proteins, Disease Models, Animal, Interferon-B, Cell culture, Interferon Type I, Cancer research, Female, Surgery, business |
| الوصف: | The antitumor effects of Interferon-beta (IFN-beta) are due to its direct inhibition of cell proliferation, immunostimulatory activity, and the inhibition of angiogenesis. We investigated the mechanism of the effects of IFN-beta on a murine colon 26 cell line (CT 26) and its highly metastatic variant (L5).We examined its inhibitory effects on cell proliferation in vitro and the development of liver metastases in vivo.The proliferation of CT 26 in vitro was inhibited by IFN-beta in a dose- and time-dependent manner. The number of metastases was reduced in mice inoculated with CT 26 (P0.01) and L5 (P0.01) on Day 14 after treatment with IFN-beta. The median survival rate of the mice inoculated with L5 administered IFN-beta every other day, or every day was higher than in the control group (P0.05). A dorsal air sac assay demonstrated that IFN-beta inhibited angiogenesis in mice inoculated with CT 26, but the effects disappeared with aminoguanidine, an inducible nitric oxide synthase inhibitor.These results showed that IFN-beta directly inhibits the proliferation of CT 26. In addition, the in vivo experiments suggested that IFN-beta might effectively inhibit liver metastases. |
| تدمد: | 1436-2813 0941-1291 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106b4b62114467542623c7f38a342b9f https://doi.org/10.1007/s00595-006-3418-z |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....106b4b62114467542623c7f38a342b9f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14362813 09411291 |
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