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Increased Metformin Clearance in Overweight and Obese Adolescents: A Pharmacokinetic Substudy of a Randomized Controlled Trial

التفاصيل البيبلوغرافية
العنوان: Increased Metformin Clearance in Overweight and Obese Adolescents: A Pharmacokinetic Substudy of a Randomized Controlled Trial
المؤلفون: Marja M J van der Vorst, Ron H.N. van Schaik, Anne van Rongen, Catherijne A. J. Knibbe, Vera H.M. Deneer, Maja Matic, Marloes P van der Aa
المساهمون: Clinical Chemistry
المصدر: Paediatric Drugs, 20(4), 365-374. Adis
Pediatric Drugs, 20(4), 365. Adis International Ltd
Paediatric Drugs
Pediatric Drugs, 20(4), 365-374
سنة النشر: 2018
مصطلحات موضوعية: Male, medicine.medical_specialty, Adolescent, Dose, Population, Overweight, Pediatrics, 030226 pharmacology & pharmacy, Body Mass Index, law.invention, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Pharmacokinetics, Randomized controlled trial, law, Internal medicine, medicine, Humans, Hypoglycemic Agents, Pharmacology (medical), Obesity, Original Research Article, Pediatrics, Perinatology, and Child Health, Child, education, education.field_of_study, business.industry, Body Weight, nutritional and metabolic diseases, Perinatology, Metformin, NONMEM, and Child Health, Endocrinology, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, business, Body mass index, medicine.drug
الوصف: Background In view of the increased use of metformin in obese adolescents, the aim of this study was to determine the pharmacokinetics of metformin in overweight and obese adolescents. Methods In overweight and obese adolescents receiving metformin 500 or 1000 mg twice daily for 37 weeks during a clinical trial, blood samples were collected over 8 h during an oral glucose tolerance test. Population pharmacokinetic modeling was performed using NONMEM. Results Data for 22 overweight and obese adolescents with a mean total body weight (TBW) of 79.3 kg (range 54.7–104.9), body mass index (BMI) of 29.1 kg/m2 (range 22.9–39.3), and age of 15.9 years (range 11.1–17.5) were analysed. In the model, oral clearance (CL/F) of metformin (1.17 l/min [relative standard error of 6%]) increased significantly with TBW (p
وصف الملف: application/pdf; image/pdf
تدمد: 1174-5878
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10abb9454cc2f4da13524e0b1943f205
https://doi.org/10.1007/s40272-018-0293-1
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....10abb9454cc2f4da13524e0b1943f205
قاعدة البيانات: OpenAIRE
الوصف
تدمد:11745878