Localization of a novel tumor suppressor gene associated with human oral cancer on chromosome 4q25
| العنوان: | Localization of a novel tumor suppressor gene associated with human oral cancer on chromosome 4q25 |
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| المؤلفون: | Katsuhiro Uzawa, Hideki Tanzawa, Xiao-Li Wang, F L Imai |
| المصدر: | Oncogene. 18:823-825 |
| بيانات النشر: | Springer Science and Business Media LLC, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Cancer Research, Loss of Heterozygosity, Chromosome, Microsatellite instability, Biology, medicine.disease, Loss of heterozygosity, stomatognathic diseases, Centimorgan, Chromosome 4, Gene mapping, Carcinoma, Squamous Cell, Genetics, Cancer research, medicine, Humans, Microsatellite, Polymorphic Microsatellite Marker, Genes, Tumor Suppressor, Mouth Neoplasms, Chromosomes, Human, Pair 4, Molecular Biology |
| الوصف: | Recent cytogenetic and molecular studies with highly polymorphic microsatellite markers have implicated allele loss involving chromosome 4 in several human cancers, which suggests the presence of multiple tumor suppressor gene (TSG) loci. However, there has been no detailed analysis of loss of heterozygosity (LOH) on chromosome 4 in oral squamous cell carcinoma (OSCC). To determine the location of a putative TSG associated with OSCC on chromosome 4, polymerase chain reaction (PCR) analysis of microsatellite polymorphisms corresponding to 17 loci was performed to screen 32 patients with OSCC. LOH was observed in the majority of the tumors (75%) in at least one of the loci. The loci on the long arm exhibited a significantly higher frequency of deletions (66%) than those of the short arm (25%). Among the loci tested, frequent LOH was centered at D4S1573 on 4q25, which represents a region of about 4 centimorgans (cM). However, no commonly deleted regions were found on the short arm of the chromosome. We detected microsatellite instability (MI) in 31% of the cases. MI was also observed more frequently on the long arm (28%) than the short arm (6%). Thus, our data indicate that alterations of chromosome 4 regions, especially the long arm, are associated with OSCC tumorigenesis and that the 4q25 region may harbor at least one putative TSG. |
| تدمد: | 1476-5594 0950-9232 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bced08bfdd2052baa82504efc0dc5e https://doi.org/10.1038/sj.onc.1202318 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....10bced08bfdd2052baa82504efc0dc5e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765594 09509232 |
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