Dopamine and Glutamate in Antipsychotic-Responsive compared to Antipsychotic Non-Responsive Psychosis::A Multicentre Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA)
| العنوان: | Dopamine and Glutamate in Antipsychotic-Responsive compared to Antipsychotic Non-Responsive Psychosis::A Multicentre Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA) |
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| المؤلفون: | Kira Griffiths, Lily McNamee, Richard Drake, Stephen M. Lawrie, Emma Eliasson, Emily J B Lambe, Jacek Donocik, Charlotte Stockton-Powdrell, Gareth J. Barker, Scott Semple, Alice Egerton, Laura Kassoumeri, Julian C. Matthews, Ernest H. Wagner, Laura Knight, Tracy Collier, Stephen R. Williams, Mattia Veronese, Shitij Kapur, James H. MacCabe, David J. Lythgoe, Richard Emsley, James T.R. Walters, Bill Deakin, Alexander D Shaw, Adriana Anton, Peter S. Talbot, Oliver D. Howes, Jane Lees, Shôn Lewis, Catherine J Gregory, Krish D. Singh, Anna Murphy, Philip McGuire |
| المصدر: | Egerton, A, Murphy, A, Donocik, J, Anton, A, Barker, G, Collier, T, Deakin, B, Drake, R, Eliasson, E, Emsley, R, Gregory, C, Griffiths, K, Kapur, S, Kassoumeri, L, Knight, L, Emily, L, Lawrie, S, Lees, J, Lewis, S W, Lythgoe, D, Matthews, J C, McGuire, P, Lily, M, Semple, S, Shaw, A, Singh, K, Stockton-Powdrell, C, Talbot, P S, Veronese, M, Wagner, E, Walters, J, Williams, S, Maccabe, J & Howes, O 2020, ' Dopamine and Glutamate in Antipsychotic-Responsive compared to Antipsychotic Non-Responsive Psychosis: A Multicentre Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA). ', Schizophrenia Bulletin . https://doi.org/10.1093/schbul/sbaa128 Egerton, A, Murphy, A, Donocik, J, Anton, A, Barker, G J, Collier, T, Deakin, B, Drake, R, Eliasson, E, Emsley, R, Gregory, C J, Griffiths, K, Kapur, S, Kassoumeri, L, Knight, L, Lambe, E J B, Lawrie, S M, Lees, J, Lewis, S, Lythgoe, D J, Matthews, J, McGuire, P, McNamee, L, Semple, S, Shaw, A D, Singh, K D, Stockton-Powdrell, C, Talbot, P S, Veronese, M, Wagner, E, Walters, J T R, Williams, S R, Maccabe, J H & Howes, O D 2021, ' Dopamine and Glutamate in Antipsychotic-Responsive Compared with Antipsychotic-Nonresponsive Psychosis: A Multicenter Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA) ', Schizophrenia Bulletin, vol. 47, no. 2, pp. 505-516 . https://doi.org/10.1093/schbul/sbaa128 Schizophrenia Bulletin Egerton, A, Murphy, A, Donocik, J, Anton, A, Barker, G J, Collier, T, Deakin, J F W, Drake, R, Eliasson, E, Emsley, R, Gregory, C, Griffiths, K, Kapur, S, Kassoumeri, L, Knight, L, Lambe, E J B, Lawrie, S M, Lees, J, Lewis, S, Lythgoe, D J, Matthews, J, McGuire, P K, McNamee, L, Semple, S I, Shaw, A D, Singh, K D, Stockton-Powdrell, C, Talbot, P, Veronese, M, Wagner, E, Walters, J T R, Williams, S R, MacCabe, J H & Howes, O D 2020, ' Dopamine and Glutamate in Antipsychotic-Responsive compared to Antipsychotic Non-Responsive Psychosis : A Multicentre Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA) ', Schizophrenia Bulletin . https://doi.org/10.1093/schbul/sbaa128 Egerton, A, Murphy, A, Donocik, J, Anton, A, Barker, G J, Collier, T, Deakin, B, Drake, R, Eliasson, E, Emsley, R, Gregory, C J, Griffiths, K, Kapur, S, Kassoumeri, L, Knight, L, Lambe, E J B, Lawrie, S M, Lees, J, Lewis, S, Lythgoe, D J, Matthews, J, Mcguire, P, Mcnamee, L, Semple, S, Shaw, A D, Singh, K D, Stockton-powdrell, C, Talbot, P S, Veronese, M, Wagner, E, Walters, J T R, Williams, S R, Maccabe, J H & Howes, O D 2020, ' Dopamine and Glutamate in Antipsychotic-Responsive Compared With Antipsychotic-Nonresponsive Psychosis: A Multicenter Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA) ', Schizophrenia Bulletin . https://doi.org/10.1093/schbul/sbaa128 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Psychosis, 1H-MRS, AcademicSubjects/MED00810, Dopamine, Proton Magnetic Resonance Spectroscopy, medicine.medical_treatment, Glutamic Acid, Gyrus Cinguli, antipsychotic response, treatment resistance, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Neuroimaging, Internal medicine, Humans, Medicine, Antipsychotic, Anterior cingulate cortex, medicine.diagnostic_test, business.industry, Glutamate receptor, Middle Aged, medicine.disease, Corpus Striatum, 030227 psychiatry, schizophrenia, Psychiatry and Mental health, Cross-Sectional Studies, Endocrinology, medicine.anatomical_structure, PET, Psychotic Disorders, Positron emission tomography, Schizophrenia, Positron-Emission Tomography, Female, business, 030217 neurology & neurosurgery, Antipsychotic Agents, Regular Articles, medicine.drug |
| الوصف: | The variability in the response to antipsychotic medication in schizophrenia may reflect between-patient differences in neurobiology. Recent cross-sectional neuroimaging studies suggest that a poorer therapeutic response is associated with relatively normal striatal dopamine synthesis capacity but elevated anterior cingulate cortex (ACC) glutamate levels. We sought to test whether these measures can differentiate patients with psychosis who are antipsychotic responsive from those who are antipsychotic nonresponsive in a multicenter cross-sectional study. 1H-magnetic resonance spectroscopy (1H-MRS) was used to measure glutamate levels (Glucorr) in the ACC and in the right striatum in 92 patients across 4 sites (48 responders [R] and 44 nonresponders [NR]). In 54 patients at 2 sites (25 R and 29 NR), we additionally acquired 3,4-dihydroxy-6-[18F]fluoro-l-phenylalanine (18F-DOPA) positron emission tomography (PET) to index striatal dopamine function (Kicer, min−1). The mean ACC Glucorr was higher in the NR than the R group after adjustment for age and sex (F1,80 = 4.27; P = .04). This was associated with an area under the curve for the group discrimination of 0.59. There were no group differences in striatal dopamine function or striatal Glucorr. The results provide partial further support for a role of ACC glutamate, but not striatal dopamine synthesis, in determining the nature of the response to antipsychotic medication. The low discriminative accuracy might be improved in groups with greater clinical separation or increased in future studies that focus on the antipsychotic response at an earlier stage of the disorder and integrate other candidate predictive biomarkers. Greater harmonization of multicenter PET and 1H-MRS may also improve sensitivity. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0586-7614 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f942b5e7c2d3d85aa3500f679c45dc https://kclpure.kcl.ac.uk/en/publications/9ca2ff41-86da-43f6-80e9-532395817b4c |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....10f942b5e7c2d3d85aa3500f679c45dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 05867614 |
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