Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis
| العنوان: | Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis |
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| المؤلفون: | E. Ann Yeh, Elisea De Somma, Raquel E. Gur, Julia O'Mahony, Emily Barlow-Krelina, Tracy L. Fabri, Christine Till, Ruben C. Gur, Micky K. Bacchus, Brenda Banwell, Giulia Longoni, Ritobrato Datta |
| المصدر: | NeuroImage : Clinical NeuroImage: Clinical, Vol 31, Iss, Pp 102753-(2021) |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, animal structures, Multiple Sclerosis, Adolescent, Memory, Episodic, Cognitive Neuroscience, Computer applications to medicine. Medical informatics, Emotions, Thalamus, R858-859.7, Hippocampus, Emotion identification, Neuropsychological Tests, Hippocampal formation, Audiology, Amygdala, Young Adult, Limbic system, medicine, Humans, Radiology, Nuclear Medicine and imaging, RC346-429, Child, Episodic memory, medicine.diagnostic_test, business.industry, Multiple sclerosis, Regular Article, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Neurocognitive testing, medicine.anatomical_structure, Neurology, Female, Neurology. Diseases of the nervous system, sense organs, Neurology (clinical), business |
| الوصف: | Highlights • Age- and sex-matched groups were compared on episodic memory and emotion identification outcomes. • POMS patients showed reduced accuracy on a test of word recognition. • POMS patients were slower to recognize faces that were recently presented. • Total and regional hippocampal, amygdala, and thalamic volumes are lower in POMS. • Memory for words was associated with both hippocampal and thalamic volume. Objective The limbic system is involved in memory and in processing of emotional stimuli. We measured volume of the hippocampus, amygdala, and thalamus, and assessed their relative contribution to episodic memory and emotion identification in POMS. Method Sixty-five POMS participants (Mage = 18.3 ± 3.9 years; 48 female (73.8%)), average disease duration = 3.8 ± 3.8 years) and 76 age- and sex-matched controls (Mage = 18.1 ± 4.6 years; 49 female (64.5%)) completed the Penn Computerized Neurocognitive Battery (PCNB); 59 of 65 POMS participants and 69 out of 76 controls underwent 3 T MRI scanning. We derived age-adjusted Z-scores on accuracy and response time (RT) measures of episodic memory and emotion identification of the PCNB. Magnetic resonance imaging (MRI) volumetrics were normalized using the scaling factor computed by SIENAx. On PCNB tests that differed between groups, we used multiple linear regression to assess relationships between regional brain volumes and either episodic memory or emotion identification outcomes controlling for age, sex, accuracy/RT, and parental education. Results POMS participants were slower and less accurate than controls on the episodic memory domain but did not differ from controls on emotion outcomes. At the subtest level, POMS participants showed reduced accuracy on Word Memory (p = .002) and slower performance on Face Memory (p = .04) subtests. POMS participants had smaller total and regional brain volumes of the hippocampus, amygdala, and thalamus (p values ≤ 0.01). Collapsing across groups, both hippocampal and thalamic volume were significant predictors of Word Memory accuracy; hippocampal volume (B = 0.24, SE = 0.10, p = .02) was more strongly associated with Word Memory performance than thalamic volume (B = 0.16, SE = 0.05, p = .003), though the estimate with was less precise. Conclusions POMS participants showed reduced episodic memory performance compared to controls. Aspects of episodic memory performance were associated with hippocampal and thalamic volume. Emotion identification was intact, despite volume loss in the amygdala. |
| تدمد: | 2213-1582 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1111141ed40846d20958373619acc1ec https://doi.org/10.1016/j.nicl.2021.102753 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1111141ed40846d20958373619acc1ec |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 22131582 |
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