Enhanced ultrasound-guided versus non-enhanced ultrasound-guided percutaneous needle biopsy in tissue cellularity of lung malignancies: a propensity score matched study
| العنوان: | Enhanced ultrasound-guided versus non-enhanced ultrasound-guided percutaneous needle biopsy in tissue cellularity of lung malignancies: a propensity score matched study |
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| المؤلفون: | Dazhi, Zhou, Yuxin, Zhang, Wuxi, Chen, Juhong, Jiang, Yanbin, Chen, Xinghua, Zhou, Qing, Tang |
| المصدر: | Quantitative Imaging in Medicine and Surgery. 12:5056-5067 |
| بيانات النشر: | AME Publishing Company, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Radiology, Nuclear Medicine and imaging |
| الوصف: | Though ultrasound-guided percutaneous lung needle biopsy (US-PLNB) is a first-line small biopsy method for peripheral lung lesions, quality of cellularity in specimens obtained via US-PLNB is uncertain. This study investigated the accuracy, sensitivity, and cellularity of US-PLNB. It examined the ability of contrast-enhanced ultrasound (CEUS) to improve the effectiveness of US-PLNB.We retrospectively analyzed all data of patients with subpleural lung lesions who underwent US-PLNB. The cellularity of US-PLNB from malignant lesions included the tumor cell number and proportion. The definition of high-quality cellularity (HQC) was concurrently achieving a tumor cell number ≥400 and a proportion ≥20%. The sensitivity, the actual numbers of tumor cell number/proportion, and the rate of HQC were calculated and compared between the CEUS and non-enhanced US groups after propensity score matching (PSM) with subgroup analyses by lesion size (small lesion ≤30 mm and large lesion30 mm).A total of 345 patients undergoing 345 US-PLNBs were evaluated, with 3.7±1.1 of punctures on average. There were 201 malignant and 144 benign lesions with a mean size of 43.8±24.1 mm. Among the 201 malignant lesions, 124 cases underwent CEUS and 77 underwent non-enhanced US. The quantity of tumor cells, the proportion of tumor cells, and the rate of HQC in 201 cases of US-PLNB from malignant lesions were 2,862.1±2,288.0, 44.6%±24.5%, and 82.1% [95% confidence interval (CI): 76.6% to 87.1%], respectively. The quantity of tumor cells, the proportion of tumor cells, and rate of HQC were significantly higher in the CEUS group than that in the non-enhanced US group, both in the analysis of overall malignant lesions and in large malignant lesions (all P0.05).The US-PLNB has high sensitivity and thereby obtains HQC samples for subpleural lung malignant lesions. The CEUS helps improve the rate of HQC and tissue cellularity of lung malignancies. |
| تدمد: | 2223-4306 2223-4292 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11214a3634d8aa019e2704735eab692d https://doi.org/10.21037/qims-22-119 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....11214a3634d8aa019e2704735eab692d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22234306 22234292 |
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