Transferrin-binding proteins isolated from Neisseria meningitidis elicit protective and bactericidal antibodies in laboratory animals

التفاصيل البيبلوغرافية
العنوان: Transferrin-binding proteins isolated from Neisseria meningitidis elicit protective and bactericidal antibodies in laboratory animals
المؤلفون: M. Mignon, M.-J. Quentin-Millet, L. Lissolo, Anthony B. Schryvers, P. Dumas, Bernard Danve, S. Colombani
المصدر: Vaccine. 11(12)
سنة النشر: 1993
مصطلحات موضوعية: Male, medicine.medical_treatment, Transferrin receptor, Mice, Inbred Strains, Passive immunity, Biology, Neisseria meningitidis, Active immunization, medicine.disease_cause, Microbiology, Mice, Bacterial Proteins, Iron-Binding Proteins, medicine, Animals, chemistry.chemical_classification, Antiserum, Antigens, Bacterial, General Veterinary, General Immunology and Microbiology, Immune Sera, Vaccination, Public Health, Environmental and Occupational Health, Immunization, Passive, Iron-binding proteins, Transferrin-Binding Proteins, Virology, Antibodies, Bacterial, Meningococcal Infections, Infectious Diseases, chemistry, Transferrin, biology.protein, Molecular Medicine, Female, Rabbits, Antibody, Carrier Proteins
الوصف: Transferrin-binding proteins (Tbps) were affinity-isolated from group B Neisseria meningitidis strain B16B6 and used to raise specific antisera. Administration of the antisera to mice loaded with human transferrin before bacterial challenge significantly protected the animals from death. In active immunization studies, mice received three 25 micrograms injections of purified Tbps over a period of 28 days, 7 days after which they were challenged with N. meningitidis. The survival rate in immunized mice was much higher than in control groups. In both active and passive immunization experiments mice were protected against at least 100 LD50. A specific Tbp antiserum was highly bactericidal against the parent strain and against approximately half of the strains tested.
تدمد: 0264-410X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113b298274543eba4a55eee486163dc7
https://pubmed.ncbi.nlm.nih.gov/8256502
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....113b298274543eba4a55eee486163dc7
قاعدة البيانات: OpenAIRE