Amoxicillin/Clavulanic Acid-Induced Thrombocytopenia
| العنوان: | Amoxicillin/Clavulanic Acid-Induced Thrombocytopenia |
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| المؤلفون: | Paul Khoueiry, Aline Saad, Marina Azar, Hanine Mansour |
| المصدر: | Hospital Pharmacy. 49:956-960 |
| بيانات النشر: | SAGE Publications, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Pharmacology, medicine.medical_specialty, Amoxicillin/clavulanic acid, Low platelet count, business.industry, Case Report, Signs and symptoms, Pharmacy, Gastroenterology, Internal medicine, Medicine, Pharmacology (medical), Platelet, Adverse effect, business, medicine.drug |
| الوصف: | Introduction and ObjectiveDrug-induced thrombocytopenia is a common adverse effect reported in the literature. Typically patients present with a low platelet count with signs and symptoms ranging from bruising to bleeding, and major organ damage. Penicillin-induced thrombocytopenia previously reported in the literature is explained primarily through the hapten-dependent antibody process. The goal of this report is to present a case of an amoxicillin/clavulanic acid-induced thrombocytopenia.Case PresentationA 23-year-old male presented to the emergency department with bruises on his arms and legs after completing a full course of amoxicillin/clavulanic acid of 625 mg twice a day for 5 days for tonsillitis. After several tests, the patient was diagnosed with thrombocytopenia induced by amoxicillin/clavulanic acid. The patient was treated with a corticosteroids taper regimen for 3 weeks. He was discharged after 3 days of inpatient treatment with instructions to avoid physical activity for 2 weeks. Two weeks post discharge, the follow-up showed that the platelet count had increased.DiscussionPenicillin-induced thrombocytopenia has been previously reported in the inpatient setting where bleeding was observed. However, the patient in this case report presented with bruises on his arms and legs. The diagnosis was made by the process of elimination; not all possible tests were conducted. The patient was prescribed corticosteroids that are not indicated for drug-induced thrombocytopenia. The Naranjo scale showed that this is a probable adverse event of amoxicillin/clavulanic acid.ConclusionThis is a unique case where amoxicillin/clavulanic acid was reported to be a probable cause of thrombocytopenia in an outpatient setting without signs of bleeding and without concomitant medications. |
| تدمد: | 1945-1253 0018-5787 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118d27a1b6231ec14ccb3af159ddd902 https://doi.org/10.1310/hpj4910-956 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....118d27a1b6231ec14ccb3af159ddd902 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19451253 00185787 |
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