Treatment of Post-Coarctectomy Hypertension With Labetalol—A 9-Year Single-Center Experience
| العنوان: | Treatment of Post-Coarctectomy Hypertension With Labetalol—A 9-Year Single-Center Experience |
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| المؤلفون: | Carolien Siersma, Carole N. M. Brouwer, Vladimir Sojak, Arend D. J. Ten Harkel, Peter P. Roeleveld |
| المصدر: | World Journal for Pediatric and Congenital Heart Surgery, 13(6), 701-706. SAGE PUBLICATIONS INC |
| بيانات النشر: | SAGE Publications, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Nitroprusside, coarctation, congenital heart surgery, Blood Pressure, General Medicine, aortic operation, Postoperative Complications, pediatric, Hypertension, Pediatrics, Perinatology and Child Health, Humans, Labetalol, Surgery, Child, Cardiology and Cardiovascular Medicine, Antihypertensive Agents, database, Retrospective Studies, intensive care |
| الوصف: | Background Although considering the pathophysiology of post-coarctectomy hypertension, β-blockers should be effective, experience with labetalol for treatment is limited in the literature. Methods Retrospective collection and analysis of data in children aged ≤6 years following coarctectomy in our tertiary care university medical center between January 2009 and June 2018. Results 96 patients were included, 45 were treated with intravenous labetalol and 51 received no treatment. Median time to maximum dose received (median 1.1 mg/kg/h) was 2.7 h, and median time to the reduction of labetalol dose was 8.3 h. No antihypertensives had to be added. In one child, labetalol was switched to nitroprusside due to bronchoconstriction. Of patients receiving intravenous labetalol, 48% had been switched to oral labetalol at discharge. Conclusions Intravenous labetalol is a fast, effective, and safe drug to treat hypertension following aortic coarctation repair. Labetalol is easily converted to oral therapy when the continuation of treatment is considered necessary. |
| تدمد: | 2150-136X 2150-1351 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1191b39318c8f5a1714b389ee07dfdf3 https://doi.org/10.1177/21501351221111797 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1191b39318c8f5a1714b389ee07dfdf3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2150136X 21501351 |
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