Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype
| العنوان: | Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype |
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| المؤلفون: | Maria Yu. Mintseva, Igor Andreev, Lev Uralsky, A.D. Manakhov, Evgeny I. Rogaev, Tatiana Andreeva, O. V. Trapezov |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-6 (2020) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Coat, Genotype, lcsh:Medicine, medicine.disease_cause, Genome, Article, Neovison, 03 medical and health sciences, biology.animal, medicine, Sequencing, Animals, Mink, American mink, Animal Fur, lcsh:Science, Gene, Genetics, Whole genome sequencing, Mutation, Multidisciplinary, 030102 biochemistry & molecular biology, biology, Base Sequence, integumentary system, Pigmentation, lcsh:R, Genomics, biology.organism_classification, 030104 developmental biology, Phenotype, rab GTP-Binding Proteins, lcsh:Q |
| الوصف: | Over 35 fur colours have been described in American mink (Neovison vison), only six of which have been previously linked to specific genes. Moyle fur colour belongs to a wide group of brownish colours that are highly similar to each other, which complicates selection and breeding procedures. We performed whole genome sequencing for two American minks with Moyle (m/m) and Violet (a/a m/m /p/p) phenotypes. We identified two frame-shift mutations in the gene encoding Ras-related protein-38 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes. The results highlight the role of RAB38 in the biogenesis of melanosomes and melanin and the genetic mechanism contributing to hair colour variety and intensity. These data are also useful for tracking economically valuable fur traits in mink breeding programmes. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d5d7744e2271cb93e522c5cffa273a http://link.springer.com/article/10.1038/s41598-020-72239-5 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....11d5d7744e2271cb93e522c5cffa273a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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