Effect of glial cells on remyelination after spinal cord injury
| العنوان: | Effect of glial cells on remyelination after spinal cord injury |
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| المؤلفون: | Ping Zhang, Guoyue Lv, Hai-Feng Wang, Ze Chu, Chun-Li Wang, Xingkai Liu, Yan Li, Yuanyi Wang, Guangyi Wang, Rui Li, Hua-Rui Liu, Bin Liu, Jun Qi |
| المصدر: | Neural Regeneration Research, Vol 12, Iss 10, Pp 1724-1732 (2017) Neural Regeneration Research |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Central nervous system, Oligodendrocyte progenitor, oligodendrocytes, microglia, oligodendrocyte precursor cells, Review, lcsh:RC346-429, Glial scar, 03 medical and health sciences, Myelin, 0302 clinical medicine, Developmental Neuroscience, medicine, Remyelination, nerve regeneration, spinal cord injury, remyelination, astrocytes, glial scar, demyelination, myelin, central nervous system, neural regeneration, Spinal cord injury, lcsh:Neurology. Diseases of the nervous system, Microglia, business.industry, medicine.disease, Crosstalk (biology), 030104 developmental biology, medicine.anatomical_structure, business, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial cells are the most abundant cells in the central nervous system. When spinal cord injury occurs, many glial cells at the lesion site are immediately activated, and different cells differentially affect inflammatory reactions after injury. In this review, we aim to discuss the core role of oligodendrocyte precursor cells and crosstalk with the rest of glia and their subcategories in the remyelination process. Activated astrocytes influence proliferation, differentiation, and maturation of oligodendrocyte precursor cells, while activated microglia alter remyelination by regulating the inflammatory reaction after spinal cord injury. Understanding the interaction between oligodendrocyte precursor cells and the rest of glia is necessary when designing a therapeutic plan of remyelination after spinal cord injury. |
| اللغة: | English |
| تدمد: | 1673-5374 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12121c4d4e19f927fd4007de58b7edb7 http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=10;spage=1724;epage=1732;aulast= |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....12121c4d4e19f927fd4007de58b7edb7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16735374 |
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