Effect of intrasite vancomycin powder on development of epidural fibrosis
| العنوان: | Effect of intrasite vancomycin powder on development of epidural fibrosis |
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| المؤلفون: | Corrado Minimo, Mark Ayzenberg, John A. Handal, Michael Narvaez, Benjamin B. Clippinger, Dillon Arango, Joshua M. Pahys |
| المصدر: | Orthopedic Reviews, Vol 10, Iss 4 (2018) |
| بيانات النشر: | Open Medical Publishing, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Orthopedic surgery, medicine.medical_specialty, business.industry, medicine.medical_treatment, Statistical difference, Laminectomy, Surgical wound, Epidural fibrosis, medicine.disease, Surgery, 03 medical and health sciences, 0302 clinical medicine, Spine surgery, Fibrosis, medicine, Vancomycin, Intrasite, vancomycin, powder, epidural, fibrosis, spine, infection, Orthopedics and Sports Medicine, 030212 general & internal medicine, business, 030217 neurology & neurosurgery, RD701-811, medicine.drug, Lumbar laminectomy |
| الوصف: | Placement of vancomycin powder into the surgical wound prior to closure has been shown to reduce postoperative infections in spine surgery. This study examines the effect of vancomycin powder on formation of epidural fibrosis (EF). Twenty-two rats underwent a two-level lumbar laminectomy. A control group, a low-dose and a high dose vancomycin powder (applied prior to closure) group was formed. Rats were sacrificed at 30 days and a blinded fellowshiptrained pathologist evaluated the laminectomy segments for EF. 50% of the samples in the high-dose vancomycin group were EF grade 3, compared to 20% of the low-dose and 16.7% of control samples. The average fibrosis grade for the high dose, low dose and control groups were 2.4, 1.4 and 1.8, respectively. There were more grade 3 EF specimens in the high dose vancomycin group. While the average EF grade was also higher in this group, there was not a statistical difference compared with the other groups. |
| اللغة: | English |
| تدمد: | 2035-8164 2035-8237 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12259a2b4171a1afee298bd4f2df7caf https://www.pagepress.org/journals/index.php/or/article/view/7777 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....12259a2b4171a1afee298bd4f2df7caf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20358164 20358237 |
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