التفاصيل البيبلوغرافية
العنوان:
Data from Infiltration of Lynch Colorectal Cancers by Activated Immune Cells Associates with Early Staging of the Primary Tumor and Absence of Lymph Node Metastases
المؤلفون:
Hans Morreau , Tom van Wezel , Hans F.A. Vasen , Frederik J. Hes , Carli M.J. Tops , Ekaterina S. Jordanova , Danny Goudkade , Noel F.C.C. de Miranda
بيانات النشر:
American Association for Cancer Research (AACR), 2023.
سنة النشر:
2023
الوصف:
Purpose: Lynch syndrome colorectal cancers often lose human leukocyte antigen (HLA) class I expression. The outgrowth of clones with immune evasive phenotypes is thought to be positively selected by the action of cytotoxic T cells that target HLA class I–positive cancer cells. To investigate this hypothesis, we related the type and density of tumor lymphocytic infiltrate in Lynch colorectal cancers with their HLA class I phenotype and clinicopathologic stage.Experimental Design: HLA class I expression was assessed by means of immunohistochemistry. Characterization of tumor-infiltrating lymphocytes was carried out by using a triple immunofluorescence procedure that allowed the simultaneous detection of CD3-, CD8-, and granzyme B (GZMB)-positive cells. Additional markers were also used for further characterization of an elusive CD3−/CD8−/GZMB+ cell population.Results: We discovered that high tumor infiltration by activated CD8+ T cells correlated with aberrant HLA class I expression and associated with early tumor stages (P < 0.05). CD8+ T cells were most abundant in HLA class I heterogeneous tumors (P = 0.02) and frequent in HLA class I–negative cases (P = 0.04) when compared with HLA class I–positive carcinomas. An elusive immune cell population (CD45+/CD8−/CD56−/GZMB+) was characteristic for HLA class I–negative tumors lacking lymph node metastases (P < 0.01).Conclusions: The immune system assumes an important role in counteracting the progression of Lynch colorectal cancers and in selecting abnormal HLA class I phenotypes. Our findings support the development of clinical strategies that explore the natural antitumor immune responses occurring in Lynch syndrome carriers. Clin Cancer Res; 18(5); 1237–45. ©2012 AACR.
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122a11edc58faf7172628912ab23d18f https://doi.org/10.1158/1078-0432.c.6519699
حقوق:
OPEN
رقم الأكسشن:
edsair.doi.dedup.....122a11edc58faf7172628912ab23d18f
قاعدة البيانات:
OpenAIRE
