Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases
| العنوان: | Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases |
|---|---|
| المؤلفون: | Barbara Bassani, Giampietro Farronato, Marco Tremolati, Luca Parisi, Elisabetta Gini, Antonino Bruno |
| المصدر: | Journal of Immunology Research, Vol 2017 (2017) Journal of Immunology Research |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, 0301 basic medicine, Immunology, Inflammation, Review Article, Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Diabetes mellitus, medicine, Animals, Humans, Immunology and Allergy, Periodontitis, Pathological, Metabolic Syndrome, Innate lymphoid cell, Cancer, Neurodegenerative Diseases, General Medicine, medicine.disease, Phenotype, Killer Cells, Natural, 030104 developmental biology, 030220 oncology & carcinogenesis, Chronic Disease, medicine.symptom, lcsh:RC581-607 |
| الوصف: | Inflammation, altered immune cell phenotype, and functions are key features shared by diverse chronic diseases, including cardiovascular, neurodegenerative diseases, diabetes, metabolic syndrome, and cancer. Natural killer cells are innate lymphoid cells primarily involved in the immune system response tonon-self-components but their plasticity is largely influenced by the pathological microenvironment. Altered NK phenotype and function have been reported in several pathological conditions, basically related to impaired or enhanced toxicity. Here we reviewed and discussed the role of NKs in selected, different, and “distant” chronic diseases, cancer, diabetes, periodontitis, and atherosclerosis, placing NK cells as crucial orchestrator of these pathologic conditions. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123e4065ebcf6533770423a9ed1d96ac http://hdl.handle.net/11383/2129250 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....123e4065ebcf6533770423a9ed1d96ac |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |