Dynamics of the Immune Response in Acute Hepatitis B Infection
| العنوان: | Dynamics of the Immune Response in Acute Hepatitis B Infection |
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| المؤلفون: | Hendrik W. Reesink, S.B. Willemse, Ester M. M. van Leeuwen, Karel A. van Dort, M.J. Sinnige, Annikki de Niet, Neeltje A. Kootstra, Robin Erken, Hans L. Zaaijer, F. Stelma |
| المساهمون: | Gastroenterology and Hepatology, Graduate School, AII - Infectious diseases, APH - Aging & Later Life, Other departments, Experimental Immunology, Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, Amsterdam Gastroenterology Endocrinology Metabolism |
| المصدر: | Open Forum Infectious Diseases Open forum infectious diseases, 4(4). Oxford University Press |
| بيانات النشر: | Oxford University Press (OUP), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, HBsAg, medicine.medical_treatment, TRAIL, NK cells, medicine.disease_cause, Virus, Major Articles, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Hepatitis B virus, acute hepatitis B, business.industry, virus diseases, Hepatitis B, HBV-specific T cells, medicine.disease, digestive system diseases, Chronic infection, 030104 developmental biology, Infectious Diseases, Cytokine, Oncology, Immunology, 030211 gastroenterology & hepatology, business, CD8 |
| الوصف: | Background Acute hepatitis B virus infection in adults is generally self-limiting but may lead to chronicity in a minority of patients. Methods We included 9 patients with acute hepatitis B virus (HBV) infection and collected longitudinal follow-up samples. Natural killer (NK) cell characteristics were analyzed by flowcytometry. HBV-specific T-cell function was analyzed by in vitro stimulation with HBV peptide pools and intracellular cytokine staining. Results Median baseline HBV DNA load was 5.12 log IU/mL, and median ALT was 2652 U/mL. Of 9 patients, 8 cleared HBsAg within 6 months whereas 1 patient became chronically infected. Early time points after infection showed increased CD56bright NK cells and an increased proportion of cells expressing activation markers. Most of these had normalized at week 24, while the proportion of TRAIL-positive CD56bright NK cells remained high in the chronically infected patient. In patients who cleared HBV, functional HBV-specific CD8+ and CD4+ responses could be observed, whereas in the patient who developed chronic infection, only low HBV-specific T-cell responses were observed. Conclusions NK cells are activated early in the course of acute HBV infection. Broad and multispecific T-cell responses are observed in patients who clear acute HBV infection, but not in a patient who became chronically infected. |
| تدمد: | 2328-8957 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1242b853aa08d137c4d90f6733104510 https://doi.org/10.1093/ofid/ofx231 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1242b853aa08d137c4d90f6733104510 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23288957 |
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