Long-term durability and safety of fecal microbiota transplantation for recurrent or refractory Clostridioides difficile infection with or without antibiotic exposure
| العنوان: | Long-term durability and safety of fecal microbiota transplantation for recurrent or refractory Clostridioides difficile infection with or without antibiotic exposure |
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| المؤلفون: | Yogita Patel, Seong Ran Jeon, Christine H. Lee, Christiana Goldeh, Jocelyn Chai, Peter T. Kim, Keely Hammond |
| المصدر: | European Journal of Clinical Microbiology & Infectious Diseases. 38:1731-1735 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, 030106 microbiology, Antibiotics, Enema, Tertiary Care Centers, Feces, 03 medical and health sciences, 0302 clinical medicine, Medical microbiology, Refractory, Recurrence, Surveys and Questionnaires, Internal medicine, medicine, Humans, 030212 general & internal medicine, Colitis, Aged, Aged, 80 and over, Clostridioides difficile, business.industry, Microbiota, Probiotics, General Medicine, Fecal bacteriotherapy, Fecal Microbiota Transplantation, Middle Aged, medicine.disease, Ulcerative colitis, Anti-Bacterial Agents, Treatment Outcome, Infectious Diseases, Clostridium Infections, Female, business, Clostridioides, Follow-Up Studies |
| الوصف: | Fecal microbiota transplant (FMT) is a safe and effective treatment for recurrent or refractory Clostridioides (Clostridium) difficile infection (RCDI) in the short term. However, there are a paucity of data on long-term durability and safety of FMT. The aim of this study is to determine the long-term efficacy and safety of FMT for RCDI. Ninety-four patients underwent FMT via retention enema for RCDI between 2008 and 2012 and completed a follow-up questionnaire 4 to 8 years following the last FMT. Of these, 32 were unreachable and 37 were deceased; 23 of the remaining 25 participants completed the survey. No CDI recurrences were reported in patients treated with FMT; 12 of the 23 participants (52.2%) received at least one course of non-CDI antibiotic(s). Nine participants (40.9%) received probiotics and 4 (17.4%) received both non-CDI antibiotics and probiotics. All 23 participants rated their overall health compared with pre-FMT. Current health was considered "much better" in 17 patients (73.9%); "somewhat better" in 3 patients (13.0%); and "about the same" in 3 patients (13.0%). A total of 11 participants (47.8%) reported an increase in weight of more than 5 kg (kg) post-FMT and 9 participants (39.1%) reported no change in weight (± 5 kg). Four of the 23 participants (17.4%) reported improvement or resolution (undifferentiated colitis, n = 1; Crohn's disease, n = 2; ulcerative colitis, n = 1) of pre-existing gastrointestinal condition following FMT. Eight of 23 participants (34.8%) experienced new medical condition(s) post-FMT. The long-term efficacy (48-96 months) of FMT for RCDI appears to be durable even after non-CDI antibiotic use. Thirty percent had improvement of their pre-existing medical conditions following FMT; 73.9% reported "much better" overall health following FMT. |
| تدمد: | 1435-4373 0934-9723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129fb561b4039e88e492886f3fca911f https://doi.org/10.1007/s10096-019-03602-2 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....129fb561b4039e88e492886f3fca911f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14354373 09349723 |
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