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Gender Disparities in Clinical Outcome After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in the Chinese Han Population: A Cohort Study

التفاصيل البيبلوغرافية
العنوان: Gender Disparities in Clinical Outcome After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in the Chinese Han Population: A Cohort Study
المؤلفون: Cheng-fu Wang, Yong Wang, Chun-yu Fan, Bo Luan, Ai-jie Hou, Hong-wei Zhao, Yu Zhu, Qing-kun Meng, Chun-sheng Cui, Xiao-jiao Zhang, Bao-jun Chen, De-feng Luo
المصدر: Heart, Lung and Circulation. 29:1856-1864
بيانات النشر: Elsevier BV, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Ablation Techniques, Male, Pulmonary and Respiratory Medicine, China, Alcohol septal ablation, medicine.medical_specialty, Time Factors, 030204 cardiovascular system & hematology, Obstructive cardiomyopathy, 03 medical and health sciences, 0302 clinical medicine, Chinese han population, Internal medicine, Ethnicity, Heart Septum, Humans, Medicine, Ventricular outflow tract, 030212 general & internal medicine, Survival rate, Retrospective Studies, Ethanol, business.industry, Atrial fibrillation, Cardiomyopathy, Hypertrophic, Middle Aged, medicine.disease, Treatment Outcome, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Atrioventricular block, Follow-Up Studies, Cohort study
الوصف: Sex differences in the long-term prognosis of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients undergoing alcohol septal ablation (ASA) remain unclear, especially in the Chinese Han population.This cohort study included 320 HOCM Chinese Han patients who underwent ASA because of symptomatic left ventricular outflow tract (LVOT) obstruction. Patients were grouped according to sex: females (mean±standard deviation age [SD] 50.7±6.8 years) and males (mean±SD age 52.6±7.3 years). Individuals were followed over the long term.Pre-procedure, women had more symptoms (New York Heart Association [NYHA] class III-IV 67.3% vs 56.3%, p=0.03), more atrial fibrillation (23.5% vs 14.6%, p=0.047) than men. Transient complete atrioventricular block after ASA was more common in woman than in men (34.0 vs 23.4%; p=0.048). Residual LVOT gradient, post-procedural residual left ventricular wall thickness, NYHA functional class, and adverse arrhythmic events were comparable between the two groups. The 10-year survival rate (77% vs 89%, p=0.037) and the annual adverse arrhythmic event rate (1.3% vs 0.4%, p0.01) following ASA were significantly worse in women compared with men. Kaplan-Meier analysis showed a significantly lower survival in women compared with men (p=0.023). In multivariable modelling, female sex remained independently associated with higher all-cause mortality (hazard ratio, 1.12; 95% confidence interval, 1.08-1.27; p=0.03) when adjusted for age, NYHA class III-IV symptoms, and other cardiovascular comorbidities.Female patients with HOCM undergoing ASA tended to have more severe symptoms and adverse arrhythmic events. The 10-year survival rate after ASA was significantly worse in women compared with men with HOCM. Sex may need to be considered as an important factor in the clinical management of patients with symptomatic HOCM.
تدمد: 1443-9506
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e827d15f02551d6a13f16f554ec0a2
https://doi.org/10.1016/j.hlc.2020.04.014
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....12e827d15f02551d6a13f16f554ec0a2
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14439506