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Gray and white matter changes and their relation to illness trajectory in first episode psychosis

التفاصيل البيبلوغرافية
العنوان: Gray and white matter changes and their relation to illness trajectory in first episode psychosis
المؤلفون: Eva Grasa-Bello, Erick J. Canales-Rodríguez, Edith Pomarol-Clotet, Iluminada Corripio, Maria J. Portella, Anna Alonso-Solís, Enric Álvarez, Alejandro Keymer-Gausset, Rosa B. Sauras-Quetcuti
المصدر: EUROPEAN NEUROPSYCHOPHARMACOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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بيانات النشر: ELSEVIER, 2018.
سنة النشر: 2018
مصطلحات موضوعية: Adult, Male, Psychosis, First episode psychosis, Inferior frontal gyrus, Neuroimaging, computer.software_genre, Corpus callosum, behavioral disciplines and activities, White matter, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Voxel, Fasciculus, Fractional anisotropy, Image Processing, Computer-Assisted, medicine, Humans, Pharmacology (medical), Gray Matter, Gray matter, Biological Psychiatry, Psychiatric Status Rating Scales, Pharmacology, biology, business.industry, Anatomy, medicine.disease, biology.organism_classification, Prognosis, White Matter, 030227 psychiatry, Psychiatry and Mental health, Diffusion Tensor Imaging, medicine.anatomical_structure, Psychotic Disorders, Neurology, Schizophrenia, Anisotropy, Female, Neurology (clinical), business, computer, 030217 neurology & neurosurgery
الوصف: Previous works have studied structural brain characteristics in first-episode psychosis (FEP), but few have focused on the relation between brain differences and illness trajectories. The aim of this study is to analyze gray and white matter changes in FEP patients and their relation with one-year clinical outcomes. A sample of 41 FEP patients and 41 healthy controls (HC), matched by age and educational level was scanned with a 3 T MRI during the first month of illness onset. One year later, patients were assigned to two illness trajectories (schizophrenia and non schizophrenia). Voxel-based morphometry (VBM) was used for gray matter and Tract-based spatial statistics (TBSS) was used for white matter data analysis. VBM revealed significant and widespread bilateral gray matter density differences between FEP and HC groups in areas that included the right insular Cortex, the inferior frontal gyrus and orbito-frontal cortices, and segments of the occipital cortex. TBSS showed a significant lower fractional anisotropy (FA) in 8 clusters that included segments of the anterior thalamic radiation, the left body and forceps minor of corpus callosum, the right anterior segment of the inferior fronto-occipital fasciculus and the anterior segments of the cingulum. The sub-groups comparison revealed significant lower FA in the schizophrenia sub-group in two clusters: the anterior thalamic radiation and the anterior segment of left cingulum. These findings are coherent with previous morphology studies. The results suggest that gray and white matter abnormalities are present at early stages of the disease, and white matter differences may distinguish different illness prognosis. (C) 2018 Elsevier B.V. and ECNP. All rights reserved.
تدمد: 0924-977X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1351934d87163a73859771bf380a6601
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3882
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....1351934d87163a73859771bf380a6601
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0924977X