Preparation of Hydrophilic Polyhydroxyalkyl Glutamine Crosslinked Films and its Biodegradability
| العنوان: | Preparation of Hydrophilic Polyhydroxyalkyl Glutamine Crosslinked Films and its Biodegradability |
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| المؤلفون: | Qin-Mei Wang, Shi-Rong Pan, Wu Yi |
| المصدر: | Journal of Biomaterials Applications. 22:181-192 |
| بيانات النشر: | SAGE Publications, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Carbon chain, Swelling ratio, Materials science, Spectrophotometry, Infrared, Hydrolysis, Biomedical Engineering, Biocompatible Materials, Alcohol, Diamines, Biodegradation, Amino Alcohols, Biomaterials, Glutamine, chemistry.chemical_compound, Cross-Linking Reagents, Aminolysis, Polyglutamic Acid, chemistry, Diamine, Materials Testing, Papain, Polymer chemistry, Organic chemistry, Octane |
| الوصف: | Polybenzyl glutamate (PBLG) or polymethyl glutamate (PMLG) films have been aminolyzed with amino alcohol and crosslinked with aliphatic diamine at 60°C for 48 h simultaneously which led to the formation of crosslinked films of polyhydroxyalkyl glutamine (PHAG). ATR-IR indicates that for the aminolysis of PBLG with 2-amino-1-ethanol or 3-amino-1-propanol, benzyl glutamate almost completely turned to hydroxyalkyl glutamine, however for the aminolysis of PMLG with 5-amino-1-pentanol, methyl glutamate partially turned to hydroxypentanyl glutamine. The water-swelling test shows that water-swelling ratio Q of PHAG films from amino alcohol with longer carbon chain was smaller, the PHAG films crosslinked by 1,2-diamino ethane have the higher water-swelling ratio Q, but the PHAG films crosslinked by 1,8-diamino octane have the lower water swelling ratio Q; and PHAG films with a greater amount of crosslinking agents have high crosslinking density or the low water swelling-ratio Q for same amino alcohol and diamine. It is obvious from in vitro enzymatic hydrolysis test that specimens with smaller swelling ratio Q displayed larger T1/2, time for half weight digestion of PHAG film, that is, less biodegradability. Therefore, biodegradability of the crosslinked PHAG films can be controlled by changing amino alcohol and diamine. |
| تدمد: | 1530-8022 0885-3282 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ae14e83d66720cbd0f8aef99f167a2 https://doi.org/10.1177/0885328207074930 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....13ae14e83d66720cbd0f8aef99f167a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15308022 08853282 |
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