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Prevalence of plasmid-mediated AmpC in Enterobacteriaceae isolated from humans and from retail meat in Zagazig, Egypt

التفاصيل البيبلوغرافية
العنوان: Prevalence of plasmid-mediated AmpC in Enterobacteriaceae isolated from humans and from retail meat in Zagazig, Egypt
المؤلفون: Heba Abdallah, Karin van Dijk, Katrijn L. Rensing, Gamal A. El-mowalid, Nashwan al Naiemi, Christina M. J. E. Vandenbroucke-Grauls, Alex G. Koek
المساهمون: Medical Microbiology and Infection Prevention, Neurology, Amsterdam Reproduction & Development (AR&D), Amsterdam Gastroenterology Endocrinology Metabolism
المصدر: Antimicrobial Resistance and Infection Control, Vol 8, Iss 1, Pp 1-8 (2019)
Rensing, K L, Abdallah, H M, Koek, A, Elmowalid, G A, Vandenbroucke-Grauls, C M J E, Al Naiemi, N & van Dijk, K 2019, ' Prevalence of plasmid-mediated AmpC in Enterobacteriaceae isolated from humans and from retail meat in Zagazig, Egypt ', Antimicrobial Resistance and Infection Control, vol. 8, no. 1, 45 . https://doi.org/10.1186/s13756-019-0494-6
Antimicrobial Resistance and Infection Control
Antimicrobial Resistance and Infection Control, 8(1):45. BioMed Central
بيانات النشر: BMC, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Veterinary medicine, Meat, medicine.drug_class, 030106 microbiology, Antibiotics, Bacteremia, Microbial Sensitivity Tests, Drug resistance, Poultry, beta-Lactamases, lcsh:Infectious and parasitic diseases, Feces, 03 medical and health sciences, 0302 clinical medicine, Medical microbiology, Plasmid, Bacterial Proteins, Enterobacteriaceae, Bloodstream infection, Genotype, medicine, Prevalence, Animals, Humans, Pharmacology (medical), lcsh:RC109-216, 030212 general & internal medicine, Sheep, biology, business.industry, Research, Plasmid-mediated AmpC, Public Health, Environmental and Occupational Health, biology.organism_classification, Anti-Bacterial Agents, Gastroenteritis, Community-Acquired Infections, Group I Enterobacteriaceae, Infectious Diseases, Female, Egypt, business, Plasmids
الوصف: Background The objective of this study was to determine the prevalence of plasmid-mediated AmpC (pAmpC) among Enterobacteriaceae isolated from humans and from retail meat in Egypt. Methods Enterobacteriaceae were isolated from patients with suspected bloodstream infection, human fecal samples, retail chicken meat samples and retail sheep meat samples. All group I Enterobacteriaceae were analyzed for presence of pAmpC genes by PCR. Antibiotic susceptibility testing was performed in all pAmpC positive isolates, followed by phenotypic and genotypic ESBL and carbapenemase testing on indication. Results The prevalence of pAmpC among group I Enterobacteriaceae isolated from 225 patients with bloodstream infection was 5.6% [95%CI 2.2–13.4]. Among 100 patients with community-onset gastroenteritis the prevalence in fecal samples was 4.8% [95%CI 2.1–10.7]. The prevalence among 112 chicken carcasses and 100 sheep meat samples was 2.4% [95%CI 0.7–8.4] and 1.1% [95%CI 0.2–5.7], respectively. In half of the AmpC positive isolates we detected an ESBL gene and 2 isolates harbored a carbapenemase gene. In five isolates there was resistance to at least three important alternative antibiotic drugs. Conclusions We consider the prevalence of pAmpC in Egypt, as found in our study, moderately low. To follow future trends in prevalence of pAmpC worldwide, a standardized screening algorithm for the detection of pAmpC is needed.
اللغة: English
تدمد: 2047-2994
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bed71a57fb7f20bea940c8e80ac429
http://link.springer.com/article/10.1186/s13756-019-0494-6
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....13bed71a57fb7f20bea940c8e80ac429
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20472994