Preliminary Report on Interleukin-22, GM-CSF, and IL-17F in the Pathogenesis of Acute Anterior Uveitis
| العنوان: | Preliminary Report on Interleukin-22, GM-CSF, and IL-17F in the Pathogenesis of Acute Anterior Uveitis |
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| المؤلفون: | Jerry Chien Chieh Huang, Mark Asquith, James T. Rosenbaum, Lindsey Watson, Claire Mitchell, Matthew Schleisman, Dongseok Choi |
| المصدر: | Ocul Immunol Inflamm |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_treatment, medicine.disease_cause, Article, Interleukin 22, Pathogenesis, medicine, Humans, Immunology and Allergy, HLA-B27 Antigen, HLA-B27, business.industry, Interleukins, Interleukin-17, Innate lymphoid cell, Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin, Middle Aged, Immune dysregulation, Flow Cytometry, medicine.disease, Uveitis, Anterior, Immunity, Innate, Ophthalmology, Cytokine, Acute Disease, Immunology, Leukocytes, Mononuclear, Female, business, Axial Spondyloarthritis, Uveitis |
| الوصف: | Anterior uveitis is the most common anatomic subset of uveitis. We used fluorescence activated cell sorting to characterize T cell cytokine expression in stimulated T cell subsets from patients with HLA B27-associated acute anterior uveitis (AAU) (n=4) compared to healthy controls (n= 14) or subjects with axial spondyloarthritis (n=6). Positive findings among subjects with AAU included a statistically significant increase in stimulated granulocyte-macrophage colony stimulating factor (GM-CSF), IL-17, and IL-22 synthesized by CD8 cells, a trend for stimulated ILC (innate lymphoid cells)-3 cells to synthesize more IL-22 (p=0.07), and stimulated MAIT (mucosa associated innate lymphoid cells)-like cells that express the T cell receptor V alpha 7.2 to express IL-17A, IL-17F, and IL-22 in a greater percentage of cells relative to controls. IL-17F, GM-CSF, and IL-22 represent potentially novel targets in AAU. Our report is arguably the first to implicate IL-17F or ILC-3 and MAIT cells in the pathogenesis of AAU. |
| تدمد: | 1744-5078 0927-3948 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e17df348877652d32a76abd437f502 https://doi.org/10.1080/09273948.2019.1686156 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....13e17df348877652d32a76abd437f502 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17445078 09273948 |
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