A case-control study on correlation between the single nucleotide polymorphism of CLEC4E and the susceptibility to tuberculosis among Han people in Western China
| العنوان: | A case-control study on correlation between the single nucleotide polymorphism of CLEC4E and the susceptibility to tuberculosis among Han people in Western China |
|---|---|
| المؤلفون: | Tao Wu, Lijuan Wu, Binwu Ying, Zhenzhen Zhao, Jiajia Song, Hao Bai, Lin Jiao, Tangyuheng Liu, Juan Zhou, Yi Zhou, Nian Wang, Wen-Jing Zhou |
| المصدر: | BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021) BMC Infectious Diseases |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, China, Tuberculosis, Genotype, Disease susceptibility, Single-nucleotide polymorphism, Infectious and parasitic diseases, RC109-216, Polymorphism, Single Nucleotide, symbols.namesake, Asian People, Genetic model, Medicine, Humans, Genetic Predisposition to Disease, Lectins, C-Type, CLEC4E, Receptors, Immunologic, Gene, Alleles, business.industry, Case-control study, Single nucleotide polymorphisms, medicine.disease, Infectious Diseases, Bonferroni correction, Parasitology, Case-Control Studies, Immunology, Expression quantitative trait loci, symbols, business, Research Article |
| الوصف: | Background Tuberculosis (TB) is one of the leading causes of morbidity and mortality in Western China. Preclinical studies have suggested the protective effect of the C-type lectin receptor of family 4 member E (CLEC4E) from TB. Herein, we investigated the association between CLEC4E gene variants and TB susceptibility in a western Chinese Han population. Methods We genotyped four single nucleotide polymorphisms (SNPs) rs10841856, rs10770847, rs10770855 and rs4480590 in the CLEC4E gene using the improved multiplex ligation detection reaction (iMLDR) assay in 900 TB cases and 1534 healthy controls. Results After stratifying the whole data by sex, it was found that males exhibited mutant allele G of rs10841856 was more strongly associated with increased TB risk after Bonferroni correction (OR = 1.334, 95% CI: 1.142–1.560; P p = 0.001 after Bonferroni correction). The genetic model analysis found that rs10841856 was associated with the increased risk of TB among males under the dominant model (OR = 1.557, 95% CI = 1.228–1.984, P P Conclusions Our study revealed that rs10841856 in the CLEC4E gene might be related to increased TB risk, especially the dominant genetic model among male Han individuals from Western China |
| اللغة: | English |
| تدمد: | 1471-2334 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ebc9a93ef5090013fffb8187e83a11 https://doaj.org/article/d2516f9ed76e480f8aa4a0af3aa81dc6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....13ebc9a93ef5090013fffb8187e83a11 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712334 |
|---|