Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing
| العنوان: | Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing |
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| المؤلفون: | Alexandria-Jade Roberts, Shaorong Chen, Carolyn L. Cannon, Dongmei Zhang, Qing-Ming Qin, Paul de Figueiredo, Hsueh-Chung Lu |
| المصدر: | Pathogens, Vol 10, Iss 1506, p 1506 (2021) Pathogens |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), medicine.drug_class, medicine.medical_treatment, Antibiotics, medicine.disease_cause, antibiotics, Microbiology, Immune system, bacterial pathogens, medicine, Immunology and Allergy, Molecular Biology, Protease, General Immunology and Microbiology, biology, multidrug resistant bacteria, Pseudomonas aeruginosa, Communication, biology.organism_classification, protease neutrophil elastase, Acinetobacter baumannii, Complement system, Infectious Diseases, Neutrophil elastase, host complement system, biology.protein, Medicine, host immune system, Bacteria |
| الوصف: | Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on Acinetobacter baumannii and Pseudomonas aeruginosa to destroy factors that prevent serum-associated, complement-directed killing. The protease activity also enhances bacterial susceptibility to antibiotics in sera. These findings implicate a new paradigm where host protease activity on bacteria acts combinatorially with the host complement system and antibiotics to defeat bacterial pathogens. |
| اللغة: | English |
| تدمد: | 2076-0817 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141a572cffa513ebe919ae87fa5f10f3 https://www.mdpi.com/2076-0817/10/11/1506 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....141a572cffa513ebe919ae87fa5f10f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20760817 |
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