The Value of Blink Reflex in Early Diagnosis of Multiple Sclerosis
| العنوان: | The Value of Blink Reflex in Early Diagnosis of Multiple Sclerosis |
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| المؤلفون: | Vida Demarin, Ivan Mikula, Maristela Stojić, Lidija Dežmalj-Grbelja, Lejla Ćorić |
| المصدر: | Acta clinica Croatica Volume 60. Issue 1. Acta Clinica Croatica, Vol 60., Iss 1., Pp 10-14 (2021) Acta Clinica Croatica |
| بيانات النشر: | Sestre Milosrdnice University Hospital Center (KBC Sestre milosrdnice), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Blink reflex, Brainstem, Clinically isolated syndrome, Multiple sclerosis, medicine.medical_specialty, Efferent, Klinički izolirani sindrom, Moždano deblo, Multipla skleroza, Refleks treptaja, Internal medicine, Reaction Time, medicine, Humans, Corneal reflex, Original Scientific Papers, Blinking, medicine.diagnostic_test, business.industry, Reflex arc, Significant difference, Magnetic resonance imaging, General Medicine, medicine.disease, Early Diagnosis, medicine.anatomical_structure, Cardiology, Medicine, business, Brain Stem |
| الوصف: | The aim was to determine differences of blink reflex in clinically definite multiple sclerosis (CDMS) and clinically isolated syndrome (CIS) in patients presented with symptoms and signs of brainstem impairment. The study included 20 patients diagnosed with CDMS, 20 with CIS, and 20 healthy controls. We recorded latencies of early (R1) and late component ipsilaterally (R2) and contralaterally (R2’), and occurrence of irritative component (R3). We analyzed data on sex, age, signs of brainstem impairment and magnetic resonance imaging (MRI) findings for the presence of brainstem demyelinating lesions. There was no statistically significant difference between patient groups according to sex, age, symptoms of brainstem involvement and MRI findings. There was no statistically significant difference in R1 component latencies and R2 latencies on the right side. Latencies of R2 on the left and R2’ on the right were statistically longer in CDMS group. There was no difference in the appearance of R3 component. In conclusion, blink reflex was found to be a very sensitive and useful diagnostic tool in the assessment of brainstem structures, especially because abnormalities are seen not only in CDMS but also in CIS. Slowing of the late component as a sign of dysfunction in the efferent part of the reflex arc is not very specific but is a highly sensitive finding. Cilj je bio ispitati razliku refleksa treptaja u bolesnika s dijagnozom klinički definitivne multiple skleroze (CDMS) i klinički izoliranog sindroma (CIS) koji imaju simptome i znakove oštećenja moždanog debla. Istraživanje je obuhvatilo 20 bolesnika s dijagnozom CDMS, 20 s CIS i 20 zdravih ispitanika kao kontrolna skupina. Bilježili smo latencije rane (R1) i kasne komponente ipsilateralno (R2) i kontralateralno (R2’), kao i pojavu iritativne komponente (R3). Analizirali smo spol, dob, simptome i znakove oštećenja moždanog debla, nalaz magnetske rezonancije (MR) s obzirom na prisustvo demijelinizacijskih lezija u području moždanog debla. Nije utvrđena razlika među skupinama bolesnika s obzirom na spol, dob, prisustvo simptoma oštećenja moždanog debla te nalaz MR. Nije bilo razlike u latencijama komponente R1, kao ni u latencijama R2 na desnoj strani. Latencije komponente R2 na lijevoj strani i R2’ na desnoj strani bile su statistički duže u skupini ispitanika s CDMS. Nije bilo razlike u pojavnosti komponente R3. U zaključku, refleks treptaja je vrlo osjetljiv i koristan dijagnostički alat za procjenu funkcije moždanog debla, pogotovo zbog toga što se abnormalnosti ne vide samo u CDMS, nego i u CIS. Usporenje kasne komponente kao znak disfunkcije eferentnog dijela refleksnog luka, iako nije specifičan nalaz, pokazao se kao vrlo osjetljiv nalaz. |
| وصف الملف: | application/pdf |
| تدمد: | 0353-9466 1333-9451 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141f1ee863729512a9b885387bfe6680 https://doi.org/10.20471/acc.2021.60.01.02 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....141f1ee863729512a9b885387bfe6680 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03539466 13339451 |
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