Differential role for CD277 as a co-regulator of the immune signal in T and NK cells
| العنوان: | Differential role for CD277 as a co-regulator of the immune signal in T and NK cells |
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| المؤلفون: | Javier Celis-Gutierrez, Nassima Messal, Bruno Chetaille, Aude Sylvain, Emilie Mamessier, Sonia Pastor, Qian Wang, Marie-Laure Thibult, Yves Guillaume, Ivan Hirsch, Jacques A. Nunès, Guylène Firaguay, Daniel Olive |
| المساهمون: | Nunès, Jacques, Centre de Recherche en Cancérologie de Marseille (CRCM / U891 Inserm), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National du Cancer (# PL-06026 and # INCa/DHOS 2009), Fonctions et dysfonctions épithéliales - UFC (EA 4267) (FDE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Sichuan Provincial Center for Diseases Control and Prevention, Sichuan Government, Laboratoire d'Immunologie des Tumeurs, Université de la Méditerranée - Aix-Marseille 2-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), mamessier, emilie, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC) |
| المصدر: | European Journal of Immunology European Journal of Immunology, 2011, 41 (12), pp.3443-54. ⟨10.1002/eji.201141404⟩ European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (12), pp.3443-3454. ⟨10.1002/eji.201141404⟩ European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (12), pp.3443-54. ⟨10.1002/eji.201141404⟩ European Journal of Immunology, 2011, 41 (12), pp.3443-3454. ⟨10.1002/eji.201141404⟩ |
| بيانات النشر: | HAL CCSD, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, MESH: Antigens, CD28, MESH: Protein Isoforms, Lymphocyte Activation, Interleukin 21, MESH: NK-cell, 0302 clinical medicine, Chlorocebus aethiops, MESH: Up-Regulation, Protein Isoforms, Immunology and Allergy, Butyrophilin, MESH: Animals, IL-2 receptor, MESH: Antigens, CD, ComputingMilieux_MISCELLANEOUS, Cell Line, Transformed, 0303 health sciences, MESH: Cytokines, Janus kinase 3, CD28, MESH: CD4-Positive T-Lymphocytes, MESH: Receptors, Antigen, T-Cell, Up-Regulation, Cell biology, cell activation, Killer Cells, Natural, MESH: COS Cells, COS Cells, Interleukin 12, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, costimulatory molecules, [SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy, MESH: Natural Cytotoxicity Triggering Receptor 3, Cell activation, MESH: Killer Cells, Natural, [SDV.IMM] Life Sciences [q-bio]/Immunology, MESH: Interferon-gamma, Immunology, Receptors, Antigen, T-Cell, T cells, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Interferon-gamma, 03 medical and health sciences, Immune system, CD28 Antigens, [SDV.CAN] Life Sciences [q-bio]/Cancer, Antigens, CD, MESH: Cell Proliferation, Animals, Humans, MESH: Cell Line, Transformed, Antigen-presenting cell, MESH: Lymphocyte Activation, Cell Proliferation, 030304 developmental biology, Natural Cytotoxicity Triggering Receptor 3, MESH: Humans, Butyrophilins, MESH: T-cell, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, MESH: Cercopithecus aethiops, 030215 immunology |
| الوصف: | International audience; The human butyrophilin (BTN) 3 or CD277 molecules belong to the B7 family members and are expressed in various immune cells such as T and NK cells. Here, we show that CD277 triggering considerably enhances TCR-induced cytokine production and cell proliferation, even when another co-stimulatory molecule, CD28, is engaged. These CD277-induced additive functional effects are in accordance with the detection of early T-cell activation events such as TCR-induced cell signaling being increased upon CD277 engagement. However, we found that CD277 triggering is not involved in CD16- or NKp46-induced NK cell activation. BTN3/CD277 comprises three structurally related members, BTN3A1, BTN3A2 and BTN3A3. CD277 antibodies recognize all isoforms and we describe a differential expression of BTN3 isoforms between T and NK cells that could explain differential CD277 functions between T and NK cells. Our results show that, while T cells express all BTN3/CD277 transcripts, NK cells express mostly BTN3A2, which lacks the B30.2 intracellular domain. Furthermore, NKp30-induced cytokine production is decreased by the specific engagement of BTN3A2, but not by BTN3A1 triggering. Thus, we provide new insights into the CD277 co-stimulatory pathway that may differentially participate in the regulation of various cell-mediated immune responses. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0014-2980 1521-4141 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142387c5a8b18886265c3eef107fe758 https://doi.org/10.1002/eji.201141404 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....142387c5a8b18886265c3eef107fe758 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00142980 15214141 |
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