Influence of cyclosporin, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation
| العنوان: | Influence of cyclosporin, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation |
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| المؤلفون: | Amado Andrés, Jose L. Rodicio, José M. Morales, Manuel Rengel |
| المصدر: | Nephrology Dialysis Transplantation. 16:121-124 |
| بيانات النشر: | Oxford University Press (OUP), 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | medicine.medical_treatment, Pharmacology, Kidney Function Tests, Tacrolimus, Nephrotoxicity, Chronic allograft nephropathy, medicine, Humans, Antihypertensive Agents, Sirolimus, Transplantation, Kidney, business.industry, Immunosuppression, medicine.disease, Kidney Transplantation, Calcineurin, surgical procedures, operative, medicine.anatomical_structure, Nephrology, Hypertension, Cyclosporine, business, Immunosuppressive Agents, medicine.drug |
| الوصف: | Cyclosporin and tacrolimus have improved survival figures in organ transplantation. However, both drugs are potentially nephrotoxic. The immunosuppressive and nephrotoxic effects of both drugs appear to depend on the inhibition of calcineurin. Cyclosporin and tacrolimus cause acute (functional changes) and chronic nephrotoxicity (structural lesions in the kidney). These last important lesions include arteriolar hyalinosis, stripped interstitial fibrosis and tubular atrophy. It is possible that repeated episodes of renal ischaemia contribute to the development of chronic nephrotoxicity and then chronic allograft nephropathy. Cyclosporin and tacrolimus also induce arterial hypertension. Therefore, the beneficial effects of immunosuppression have been limited due to nephrotoxicity and arterial hypertension. Rapamycin, a novel immunosuppressive agent, that does not inhibit calcineurin, provides immunosuppression without nephrotoxicity. In fact, in the trials performed in Europe, sirolimus-treated immunosuppression patients exhibited a much better renal function than cyclosporin-treated patients. However, sirolimus can potentiate the nephrotoxic effect of cyclosporin. Therefore, when cyclosporin and sirolimus are used in combination, a reduction of the cyclosporin dose is desirable. |
| تدمد: | 1460-2385 0931-0509 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1439c138226c66dbf6b9505cf20e8865 https://doi.org/10.1093/ndt/16.suppl_1.121 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1439c138226c66dbf6b9505cf20e8865 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602385 09310509 |
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