Nanoparticle elasticity directs tumor uptake
| العنوان: | Nanoparticle elasticity directs tumor uptake |
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| المؤلفون: | Debra T. Auguste, Biran Wang, Jiang Yang, Daxing Liu, Kriti S. Subramanyam, Marsha A. Moses, Peng Guo, Jing Huang |
| المصدر: | Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018) Nature Communications |
| بيانات النشر: | Nature Publishing Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Chlorpromazine, Science, General Physics and Astronomy, Breast Neoplasms, 02 engineering and technology, Microscopy, Atomic Force, 010402 general chemistry, 01 natural sciences, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, Rheology, In vivo, Cell Line, Tumor, Elastic Modulus, Animals, Humans, Filipin, Elasticity (economics), Lipid bilayer, lcsh:Science, Elastic modulus, Mice, Inbred BALB C, Multidisciplinary, Chemistry, Hydrazones, Mammary Neoplasms, Experimental, General Chemistry, 021001 nanoscience & nanotechnology, musculoskeletal system, Endocytosis, In vitro, 0104 chemical sciences, Liver, Cell culture, Drug delivery, biological sciences, MCF-7 Cells, Biophysics, Nanoparticles, lcsh:Q, 0210 nano-technology |
| الوصف: | To date, the role of elasticity in drug delivery remains elusive due to the inability to measure microscale mechanics and alter rheology without affecting chemistry. Herein, we describe the in vitro cellular uptake and in vivo tumor uptake of nanolipogels (NLGs). NLGs are composed of identical lipid bilayers encapsulating an alginate core, with tunable elasticity. The elasticity of NLGs was evaluated by atomic force microscopy, which demonstrated that they exhibit Young’s moduli ranging from 45 ± 9 to 19,000 ± 5 kPa. Neoplastic and non-neoplastic cells exhibited significantly greater uptake of soft NLGs (Young’s modulus 13.8 MPa). In an orthotopic breast tumor model, soft NLGs accumulated significantly more in tumors, whereas elastic NLGs preferentially accumulated in the liver. Our findings demonstrate that particle elasticity directs tumor accumulation, suggesting that it may be a design parameter to enhance tumor delivery efficiency. Nanoparticle elasticity is thought to play an important role in drug delivery, but is little studied. Here, the authors use nanolipogels with tunable moduli to study the effect of particle elasticity on in vitro cellular uptake and in vivo tumor uptake, finding that stiffer particles are not as easily internalized. |
| اللغة: | English |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143cbf70c429939a4ad381d8cc214c71 http://link.springer.com/article/10.1038/s41467-017-02588-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....143cbf70c429939a4ad381d8cc214c71 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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