Efficacy of Vinblastine for Treatment of Canine Mast Cell Tumors
| العنوان: | Efficacy of Vinblastine for Treatment of Canine Mast Cell Tumors |
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| المؤلفون: | J. L. Intile, Cheryl E. Balkman, D. B. Bailey, Kenneth M. Rassnick, M. A. Kiselow, Karoliina Autio, Andrea B. Flory |
| المصدر: | Journal of Veterinary Internal Medicine. 22:1390-1396 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.medical_treatment, Antineoplastic Agents, Neutropenia, Vinblastine, Gastroenterology, Mast cell tumors, Dogs, Internal medicine, medicine, Animals, Dog Diseases, Clinical efficacy, Chemotherapy, Dose-Response Relationship, Drug, General Veterinary, Tumor size, business.industry, medicine.disease, Surgery, Clinical trial, Dose–response relationship, Female, business, Mastocytosis, medicine.drug |
| الوصف: | Background: The optimal dosage and clinical efficacy of vinblastine (VBL) for treatment of mast cell tumors (MCTs) in dogs has not been established. Hypothesis: Single-agent VBL has antitumor activity against MCTs in dogs. Animals: Fifty-one dogs with nonresectable grade II or III cutaneous MCTs. Methods: Prospective, open clinical trial. Dogs were systematically allocated (by hospital record number) to receive IV treatment with VBL at a dosage of 2.0 mg/m2 (weekly for 4 treatments then biweekly for 4 treatments; VBL 2.0) or treatment with VBL at a dosage of 3.5 mg/m2 (biweekly for 5 treatments; VBL 3.5). The primary outcome measure was reduction in tumor size. Results: Twenty-five dogs were allocated to the VBL 2.0 group and 26 were allocated to the VBL 3.5 group. In the VBL 2.0 group, 3 (12%) had a partial response (PR) for a median of 77 days (range, 48–229 days). Overall response rate in the VBL 3.5 group was 27%. One dog (4%) had a complete response for 63 days and 6 dogs (23%) had a PR for a median of 28 days (range, 28–78 days). Toxicoses were uncommon in the VBL 2.0 group. Twelve (46%) dogs in the VBL 3.5 group had |
| تدمد: | 1939-1676 0891-6640 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144853a8355bfa463284e66522423bed https://doi.org/10.1111/j.1939-1676.2008.0195.x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....144853a8355bfa463284e66522423bed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19391676 08916640 |
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