Variation in Clinical Characteristics, Outcomes, and Mortality of Hospitalized Patients with COVID-19 during the Second Wave of the Pandemic: A Single-Center Experience
| العنوان: | Variation in Clinical Characteristics, Outcomes, and Mortality of Hospitalized Patients with COVID-19 during the Second Wave of the Pandemic: A Single-Center Experience |
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| المؤلفون: | Reem Alhashemi, Kenneth Granet, Chang Wang, Chandler Patton, Ikwinder Preet Kaur, Mohsin Sheraz Mughal, Alvin Buemio |
| المصدر: | Journal of Investigative Medicine. 69:1479-1482 |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Pediatrics, medicine.medical_specialty, medicine.medical_treatment, Single Center, General Biochemistry, Genetics and Molecular Biology, law.invention, law, Severity of illness, Humans, Medicine, Hospital Mortality, Pandemics, Retrospective Studies, Mechanical ventilation, business.industry, Septic shock, Mortality rate, Acute kidney injury, COVID-19, General Medicine, medicine.disease, Respiration, Artificial, Intensive care unit, United States, Hospitalization, Respiratory failure, business |
| الوصف: | As of February 2, 2021, the USA has 26,431,799 reported COVID-19 cases with 446,744 deaths. A high mortality rate (15%–40%) was reported among hospitalized patients with COVID-19 during the first wave of the pandemic. However, data regarding variation in COVID-19-related mortality and severity of illness among hospitalized patients with COVID-19 are heterogeneous. In this retrospective single-center study, we aimed to investigate the demographic characteristics, clinical presentations, disease severity, clinical outcomes, and in-hospital mortality of hospitalized patients with COVID-19 during the second wave of the pandemic. Adults with reverse transcription-PCR-confirmed SARS-CoV-2 infection were included. In-hospital mortality due to COVID-19 was the primary outcome, and intensive care unit admission, acute kidney injury, acute respiratory distress syndrome, respiratory failure requiring intubation, and septic shock were the secondary outcomes. A total of 101 adult patients were hospitalized with COVID-19 during the second wave study period. Of 101 patients, 8 were intubated and 6 died. The median duration of hospital stay was 6 days. Patients in the second wave were more likely to receive dexamethasone and remdesivir and less likely to require invasive mechanical ventilation. In-hospital mortality during the second wave was lower (5.9%) compared with the first wave (15.5%). At the last follow-up date, 86.1% were discharged alive from the hospital, 5.9% died and 7.9% were still in the hospital. Multivariate logistic regression showed higher odds of mortality were associated with higher age and elevated lactate dehydrogenase peak. |
| تدمد: | 1708-8267 1081-5589 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1480dac8c8e085f5c71bdc6238c9c37f https://doi.org/10.1136/jim-2021-001876 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1480dac8c8e085f5c71bdc6238c9c37f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17088267 10815589 |
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