In the early 70’s FDA (United States Food and Drug administration) have realized cases of poor laboratory practice throughout the United States. FDA decided to check over 40 toxicology labs in-depth. They revealed lot dishonest activities and a lot of poor lab practices. Examples of some of these poor lab practices found were equipment not been calibrated to standard form, therefore giving wrong measurements, incorrect or inaccurate accounts of the actual lab study and incompetent test systems. Although the term “good laboratory practice” might have been used informal already for some time in many laboratories around the world GLP originated in the United States and it had a powerfull effect world wide.