Assessing the effect of antihypertensives on plaque microbiota in patients with periodontitis and hypertension using 16S rRNA sequencing: A cross‐sectional study
| العنوان: | Assessing the effect of antihypertensives on plaque microbiota in patients with periodontitis and hypertension using 16S rRNA sequencing: A cross‐sectional study |
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| المؤلفون: | Hyun‐Joo Kim, Kyu‐Won Shim, Hee Sam Na, Si Yeong Kim, Yeuni Yu, Yuri Song, Hyun Ah Lee, Ju Youn Lee, Jae‐Hyung Lee, Jin Chung |
| المصدر: | Journal of Periodontology. 94:529-541 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | General Engineering, Periodontics |
| الوصف: | Periodontitis is initiated or accelerated by dysbiosis of oral microorganisms. When hypertension is accompanied in periodontitis patients, changes of oral microbiota occur. Since there are no reports on antihypertensives, we assessed their effect on the oral microbial profiles of patients with periodontitis.This study involved 95 participants divided into two groups: those with periodontitis and hypertension (P_HT), and those with periodontitis and taking medications for hypertension (P_mHT). Plaque samples were collected from the buccal, supragingival, and subgingival sites of the oral cavities of these patients. DNA was extracted, and the V3-V4 region of the 16S ribosomal RNA was sequenced and analyzed.The P_HT and P_mHT groups were similar with respect to the alpha- and beta-diversity as well as the dominant phyla and genera, but differed in the relative abundance of bacterial species (85 species). In the P_mHT group, the relative abundance of major periodontal pathogens was greatly increased. In particular, Tannerella forsythia, Treponema denticola, and Fretibacterium fastidiosum increased nearly three times in the linear discriminant analysis score in the supragingival plaque. Also, there was an increase in the relative abundance of Prevotella spp., associated with periodontitis and nitrate reduction, which was also evident in the supragingival plaque.These findings indicate that antihypertensives induce dysbiotic changes in the oral microbiota of patients with periodontitis, which are associated with increases in the relative abundance of periodontal pathogens. Therefore, more active periodontal treatment and supportive periodontal therapy are required in patients taking antihypertensives. |
| تدمد: | 1943-3670 0022-3492 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1497af54ef0606f04decfc3fd2f974c9 https://doi.org/10.1002/jper.22-0204 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....1497af54ef0606f04decfc3fd2f974c9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19433670 00223492 |
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