Modulating transcallosal and intra-hemispheric brain connectivity with tDCS: Implications for interventions in Aphasia
| العنوان: | Modulating transcallosal and intra-hemispheric brain connectivity with tDCS: Implications for interventions in Aphasia |
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| المؤلفون: | Weiying Dai, Xin Zheng, Gottfried Schlaug, David C. Alsop |
| المصدر: | Restorative Neurology and Neuroscience. 34:519-530 |
| بيانات النشر: | IOS Press, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Stimulation, Audiology, Transcranial Direct Current Stimulation, 050105 experimental psychology, Corpus Callosum, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Developmental Neuroscience, Aphasia, Motor system, Connectome, medicine, Humans, 0501 psychology and cognitive sciences, Cerebral Cortex, Transcranial direct-current stimulation, 05 social sciences, Inferior parietal lobule, Magnetic Resonance Imaging, Healthy Volunteers, Neurology, Cerebral blood flow, Disinhibition, Cerebrovascular Circulation, Female, Spin Labels, Neurology (clinical), Analysis of variance, medicine.symptom, Psychology, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | BACKGROUND/OBJECTIVE Transcranial direct current stimulation (tDCS) can enhance or diminish cortical excitability levels depending on the polarity of the stimulation. One application of non-invasive brain-stimulation has been to modulate a possible inter-hemispheric disinhibition after a stroke. This disinhibition model has been developed mainly for the upper extremity motor system, but it is not known whether the language/speech-motor system shows a similar inter-hemispheric interaction. We aimed to examine physiological evidence of inter- and intra-hemispheric connectivity changes induced by tDCS of the right inferior frontal gyrus (IFG) using arterial-spin labeling (ASL) MRI. METHODS Using an MR-compatible DC-Stimulator, we applied anodal stimulation to the right IFG region of nine healthy adults while undergoing non-invasive cerebral blood flow imaging with arterial-spin labeling (ASL) before, during, and after the stimulation. All ASL images were then normalized and timecourses were extracted in regions of interest (ROIs), which were the left and right IFG regions, and the right supramarginal gyrus (SMG) in the inferior parietal lobule. Two additional ROIs (the right occipital lobe and the left fronto-orbital region) were taken as control regions. RESULTS Using regional correlation coefficients as a surrogate marker of connectivity, we could show that inter-hemispheric connectivity (right IFG with left IFG) decreased significantly (p |
| تدمد: | 1878-3627 0922-6028 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a03690d79ea66e008a253eed7104ce https://doi.org/10.3233/rnn-150625 |
| رقم الأكسشن: | edsair.doi.dedup.....14a03690d79ea66e008a253eed7104ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18783627 09226028 |
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