Comparison of Conventional and Radiomic Features between 18F-FBPA PET/CT and PET/MR
| العنوان: | Comparison of Conventional and Radiomic Features between 18F-FBPA PET/CT and PET/MR |
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| المؤلفون: | Chien-Yi Liao, Yi-Wei Chen, Chien-Ying Li, Chia-Feng Lu, Ren-Shyan Liu, Jun-Hsuang Jen, Wen-Sheng Huang, Ling-Wei Wang |
| المصدر: | Biomolecules Volume 11 Issue 11 Biomolecules, Vol 11, Iss 1659, p 1659 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Future studies, positron emission tomography, Intraclass correlation, PET/CT, Malignant brain tumor, malignant tumor, Boron Neutron Capture Therapy, Microbiology, Biochemistry, Quantitative accuracy, Article, Positron Emission Tomography Computed Tomography, medicine, Humans, nuclear medicine, Molecular Biology, Retrospective Studies, PET-CT, T/N ratio, 18F-FBPA, medicine.diagnostic_test, business.industry, Middle Aged, boron neutron capture therapy (BNCT), QR1-502, PET/MR, Positron emission tomography, radiomics, Wavelet filtering, business, Nuclear medicine, Correction for attenuation |
| الوصف: | Boron-10-containing positron emission tomography (PET) radio-tracer, 18F-FBPA, has been used to evaluate the feasibility and treatment outcomes of Boron neutron capture therapy (BNCT). The clinical use of PET/MR is increasing and reveals its benefit in certain applications. However, the PET/CT is still the most widely used modality for daily PET practice due to its high quantitative accuracy and relatively low cost. Considering the different attenuation correction maps between PET/CT and PET/MR, comparison of derived image features from these two modalities is critical to identify quantitative imaging biomarkers for diagnosis and prognosis. This study aimed to investigate the comparability of image features extracted from 18F-FBPA PET/CT and PET/MR. A total of 15 patients with malignant brain tumor who underwent 18F-FBPA examinations using both PET/CT and PET/MR on the same day were retrospectively analyzed. Overall, four conventional imaging characteristics and 449 radiomic features were calculated from PET/CT and PET/MR, respectively. A linear regression model and intraclass correlation coefficient (ICC) were estimated to evaluate the comparability of derived features between two modalities. Features were classified into strong, moderate, and weak comparability based on coefficient of determination (r2) and ICC. All of the conventional features, 81.2% of histogram, 37.5% of geometry, 51.5% of texture, and 25% of wavelet-based features, showed strong comparability between PET/CT and PET/MR. With regard to the wavelet filtering, radiomic features without filtering (61.2%) or with low-pass filtering (59.2%) along three axes produced strong comparability between the two modalities. However, only 8.2% of the features with high-pass filtering showed strong comparability. The linear regression models were provided for the features with strong and moderate consensus to interchange the quantitative features between the PET/CT and the PET/MR. All of the conventional and 71% of the radiomic (mostly histogram and texture) features were sufficiently stable and could be interchanged between 18F-FBPA PET with different hybrid modalities using the proposed equations. Our findings suggested that the image features high interchangeability may facilitate future studies in comparing PET/CT and PET/MR. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2218-273X |
| DOI: | 10.3390/biom11111659 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bb1c6c79987cc36ea134a802fb3274 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....14bb1c6c79987cc36ea134a802fb3274 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2218273X |
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| DOI: | 10.3390/biom11111659 |