Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing: Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression
| العنوان: | Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing: Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression |
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| المؤلفون: | Janeen H. Trembley, Pascal Loyer |
| المساهمون: | Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), University of Minnesota [Crookston], University of Minnesota System, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Jonchère, Laurent |
| المصدر: | Seminars in Cell and Developmental Biology Seminars in Cell and Developmental Biology, Elsevier, 2020, 107, pp.36-45. ⟨10.1016/j.semcdb.2020.04.016⟩ Seminars in Cell and Developmental Biology, 2020, 107, pp.36-45. ⟨10.1016/j.semcdb.2020.04.016⟩ |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Transcription, Genetic, RNA Splicing, [SDV]Life Sciences [q-bio], 03 medical and health sciences, 0302 clinical medicine, Transcription (biology), Cyclin-dependent kinase, Cyclins, CCNL2, RNA Precursors, CCNL1, Animals, Humans, cancer, Amino Acid Sequence, Cyclin L, Cyclin, Regulation of gene expression, biology, Kinase, Cell Cycle, Cell Biology, Cell cycle, Cyclin-Dependent Kinases, 3. Good health, Cell biology, [SDV] Life Sciences [q-bio], 030104 developmental biology, pre-mRNA splicing, RNA splicing, biology.protein, Phosphorylation, Transcription, 030217 neurology & neurosurgery, CDK11, Developmental Biology |
| الوصف: | International audience; Cyclin Dependent Kinases (CDKs) represent a large family of serine/threonine protein kinases that become active upon binding to a Cyclin regulatory partner. CDK/cyclin complexes recently identified, as well as "canonical" CDK/Cyclin complexes regulating cell cycle, are implicated in the regulation of gene expression via the phosphorylation of key components of the transcription and pre-mRNA processing machineries. In this review, we summarize the role of CDK/cyclin-dependent phosphorylation in the regulation of transcription and RNA splicing and highlight recent findings that indicate the involvement of CDK11/cyclin L complexes at the cross-roads of cell cycle, transcription and RNA splicing. Finally, we discuss the potential of CDK11 and Cyclins L as therapeutic targets in cancer. |
| وصف الملف: | application/pdf |
| تدمد: | 1084-9521 1096-3634 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bdc014390698c8bb477b2f0647afd8 https://doi.org/10.1016/j.semcdb.2020.04.016 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....14bdc014390698c8bb477b2f0647afd8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10849521 10963634 |
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